CRLF1 and CLCF1

Number of citations: 0 (PubMedID 10966616)
Data Source: HPRD (in vivo, in vitro)

		CRLF1	CLCF1
Name		cytokine receptor like factor 1	cardiotrophin like cytokine factor 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol External Side Of Plasma Membrane Receptor Complex CRLF-CLCF1 Complex	Extracellular Region Extracellular Space CRLF-CLCF1 Complex CNTFR-CLCF1 Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Cytokine Binding	Signaling Receptor Binding Cytokine Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Activity Receptor Ligand Activity
	Biological Process	Ureteric Bud Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Motor Neuron Apoptotic Process	Positive Regulation Of Immunoglobulin Production Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of B Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Astrocyte Differentiation Cell Surface Receptor Signaling Pathway Via STAT
Pathways		IL-6-type cytokine receptor ligand interactions Interleukin-27 signaling	IL-6-type cytokine receptor ligand interactions
Diseases		Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)	Cold-induced sweating syndrome (CISS) and Crisponi syndrome (CRISPS)
GWAS		Blood protein levels ( 30072576 ) Dentures ( 31235808 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 )	Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 )
Interacting Genes		2 interacting genes: CLCF1 CNTFR	5 interacting genes: CNTFR CRLF1 S100A1 S100A6 S100P
Entrez ID		9244	23529
HPRD ID		09177	09643
Ensembl ID		ENSG00000006016	ENSG00000175505
Uniprot IDs		O75462	Q9UBD9
PDB IDs		8D7H	8D7H 8D7R
GO Terms Enriched among Interactors		CNTFR-CLCF1 Complex Interleukin-11 Receptor Activity Signaling Receptor Binding Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Cytokine-mediated Signaling Pathway Interleukin-11 Binding Positive Regulation Of Isotype Switching To IgE Isotypes CRLF-CLCF1 Complex Ciliary Neurotrophic Factor Receptor Binding Interleukin-11-mediated Signaling Pathway Brainstem Development Suckling Behavior Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Astrocyte Differentiation Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Extrinsic Component Of Membrane Skeletal Muscle Organ Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Sex Differentiation Positive Regulation Of Isotype Switching Regulation Of Astrocyte Differentiation Regulation Of Isotype Switching Positive Regulation Of Glial Cell Differentiation Cytokine Binding Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of B Cell Proliferation Cytokine Receptor Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of B Cell Proliferation Positive Regulation Of Immunoglobulin Production Positive Regulation Of Gliogenesis Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Glial Cell Differentiation Regulation Of Cell Population Proliferation Positive Regulation Of DNA Recombination Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immunoglobulin Production Feeding Behavior Positive Regulation Of B Cell Activation Regulation Of Gliogenesis Neuron Apoptotic Process Cell Surface Receptor Signaling Pathway	Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Cell Population Proliferation Calcium-dependent Protein Binding Regulation Of Motor Neuron Apoptotic Process S100 Protein Binding Cytokine Binding Regulation Of Cell Population Proliferation Cytokine Receptor Activity Cytokine-mediated Signaling Pathway Interleukin-11 Receptor Activity Negative Regulation Of Neuron Apoptotic Process CNTFR-CLCF1 Complex Ciliary Neurotrophic Factor Receptor Activity Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Binding Regulation Of Oligodendrocyte Progenitor Proliferation Platelet Degranulation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Postsynaptic Specialization, Intracellular Component Cytoplasmic Side Of Plasma Membrane SH3 Domain Binding Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Interleukin-5-mediated Signaling Pathway Positive Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Dendritic Cell Apoptotic Process Protein Homodimerization Activity Calcium Ion Binding Ciliary Neurotrophic Factor Receptor Binding CRLF-CLCF1 Complex Synaptic Receptor Adaptor Activity Interleukin-11-mediated Signaling Pathway Phosphatidylinositol 3-kinase Activator Activity C-X-C Chemokine Receptor CXCR4 Signaling Pathway Histamine Secretion Brainstem Development Mitochondrial Crista Regulation Of Mast Cell Proliferation Signaling Receptor Activator Activity Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Histamine Transport Suckling Behavior