VAPA and ADGRG7

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		VAPA	ADGRG7
Name		VAMP associated protein A	adhesion G protein-coupled receptor G7
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Endoplasmic Reticulum Exit Site	Plasma Membrane Membrane
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Sphingomyelin Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Phospholipid Transport Sterol Transport Viral Release From Host Cell Cholesterol Transport Neuron Projection Development Protein Folding In Endoplasmic Reticulum Ceramide Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Membrane Fusion Endoplasmic Reticulum-plasma Membrane Tethering Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	None
GWAS		Diverticular disease ( 30177863 ) FEV1 ( 30804560 ) Heel bone mineral density ( 30598549 ) Lung function (FEV1/FVC) ( 30804560 ) Metabolite levels ( 23823483 ) Peak expiratory flow ( 30804560 ) Pulmonary function (smoking interaction) ( 23284291 )	No GWAS studies recorded
Interacting Genes		47 interacting genes: ADGRG7 ADRB2 APOD AQP6 BIK CACNG1 CD79A CFTR CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B13 JAGN1 KCNB1 KCNB2 LEPROTL1 NSF NXF1 OCIAD1 OPRM1 OSBP RB1CC1 RETREG3 RMDN2 RMDN3 SCN3B SEC11C SIK1 SLC16A7 SLC18A1 SLC35B1 SNX2 STARD3 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 USP40 VAMP1 VAMP2 ZBTB22	4 interacting genes: LDLRAD1 LMNA SORT1 VAPA
Entrez ID		9218	84873
HPRD ID		09299	17060
Ensembl ID		ENSG00000101558	ENSG00000144820
Uniprot IDs		Q9P0L0	B7Z303 E9PHI0 Q6ZMH4 Q96K78
PDB IDs		2RR3 6TQR	Not available
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Ascorbate Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Localization To Cell Periphery Transmembrane Monodehydroascorbate Reductase Activity Regulation Of Cellular Localization Organic Hydroxy Compound Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Regulation Of Establishment Of Protein Localization Cellular Localization Endosome Establishment Of Localization In Cell Regulation Of Protein Localization Regulation Of Protein Transport Transmembrane Transport Monoatomic Ion Transport Protein Localization To Membrane Protein Localization To Plasma Membrane ERBB2-EGFR Signaling Pathway Potassium Channel Regulator Activity Negative Regulation Of Protein Transport Syntaxin Binding Monoatomic Ion Channel Complex Organelle Membrane Contact Site Cytoplasmic Vesicle SNARE Complex Assembly Inorganic Ion Transmembrane Transport Localization Within Membrane Negative Regulation Of Establishment Of Protein Localization Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hormone Secretion Regulation Of Protein Secretion SNARE Binding Regulation Of Transport Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Cholesterol Transport Regulation Of Secretion By Cell Vesicle-mediated Transport Endosome Membrane Metal Ion Transport Negative Regulation Of Protein Secretion Syntaxin-1 Binding Protein Binding Regulation Of Insulin Secretion Inorganic Cation Transmembrane Transport	Nuclear Membrane Protein Localization To Organelle Perinuclear Region Of Cytoplasm Neurotensin Receptor Activity, Non-G Protein-coupled DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Nerve Growth Factor Receptor Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Cellular Localization Ventricular Cardiac Muscle Cell Development Nuclear Pore Localization Establishment Of Protein Localization To Organelle Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Mesenchymal Cell Proliferation Intracellular Transport Vesicle Organization Golgi To Lysosome Transport Plasma Membrane To Endosome Transport Vesicle-mediated Transport Retromer Complex Binding Golgi Vesicle Transport Nerve Growth Factor Binding Cerebellar Climbing Fiber To Purkinje Cell Synapse Endoplasmic Reticulum Localization FFAT Motif Binding Host-mediated Activation Of Viral Genome Replication COPII-coated Vesicle Budding Sphingomyelin Biosynthetic Process Endoplasmic Reticulum-plasma Membrane Tethering Host-mediated Perturbation Of Viral Genome Replication Establishment Of Localization In Cell Protein Folding In Endoplasmic Reticulum Nuclear Lamina Host-mediated Suppression Of Viral Genome Replication Protein Localization To Nuclear Envelope Golgi To Endosome Transport Nerve Growth Factor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Organelle Localization Negative Regulation Of Release Of Cytochrome C From Mitochondria Intracellular Protein Localization Golgi To Vacuole Transport Trans-Golgi Network Transport Vesicle D-glucose Import Protein Localization To Endoplasmic Reticulum Ceramide Transport Sphingomyelin Metabolic Process Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nuclear Envelope Organization