FCMR and ZNHIT3

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		FCMR	ZNHIT3
Name		Fc mu receptor	zinc finger HIT-type containing 3
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Lysosome Lysosomal Membrane Endosome Golgi Apparatus Centrosome Plasma Membrane Membrane Early Endosome Membrane Trans-Golgi Network Membrane	Nucleus Cytoplasm Pre-snoRNP Complex
	Molecular Function	Polymeric Immunoglobulin Binding IgM Binding High-affinity IgM Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Immune System Process Immunoglobulin Transcytosis In Epithelial Cells Humoral Immune Response Mediated By Circulating Immunoglobulin Cellular Defense Response Signal Transduction Fc Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of B Cell Receptor Signaling Pathway Fc Receptor-mediated Immune Complex Endocytosis	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Box C/D SnoRNP Assembly Regulation Of DNA-templated Transcription
GWAS		No GWAS studies recorded	Body mass index ( 26426971 ) Multiple sclerosis ( 31604244 ) Red cell distribution width ( 27863252 28957414 32888494 )
Interacting Genes		3 interacting genes: ANKRD2 HOXD9 ZNHIT3	13 interacting genes: CSNK2A2 ESR2 FCMR HNF4A MBNL1 MEIS2 PBX3 PITX2 PPARG RXRA THRB XRCC3 ZNF24
Entrez ID		9214	9326
HPRD ID		09349	05139
Ensembl ID		ENSG00000162894	ENSG00000273611
Uniprot IDs		O60667	Q15649
PDB IDs		7YSG 7YTC 7YTD 7YTE 8BPE 8BPF 8BPG	2YQQ 5L85
GO Terms Enriched among Interactors		None	Sequence-specific DNA Binding Nuclear Receptor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Retinoic Acid Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway DNA Binding Domain Binding Nucleoplasm Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific LBD Domain Binding MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Nucleus Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Monocyte Differentiation Eye Development Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex