LGI1 and ADAM22

Number of citations: 0 (PubMedID 16990550)
Data Source: HPRD (in vitro)

		LGI1	ADAM22
Name		leucine rich glioma inactivated 1	ADAM metallopeptidase domain 22
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Golgi Apparatus Dendrite Synaptic Cleft Axon Initial Segment Synapse Glutamatergic Synapse	Plasma Membrane Membrane Axon Cell Projection Postsynaptic Density Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Receptor Ligand Activity	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Signaling Receptor Activity
	Biological Process	Signal Transduction Nervous System Development Axon Guidance Positive Regulation Of Cell Growth Neuron Projection Development Positive Regulation Of Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Positive Regulation Of Synaptic Transmission
Pathways		LGI-ADAM interactions	LGI-ADAM interactions
Diseases		Autosomal dominant temporal lobe epilepsy (ADTLE); Autosomal dominant partial epilepsy with auditory features (ADPEAF)	None
GWAS		Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321 ) Cerebrospinal fluid AB1-42 levels ( 29274321 ) Response to (pegylated) interferon in chronic hepatitis B ( 30715261 ) Response to perphenazine in schizophrenia ( 29503163 )	Blood protein levels ( 30072576 ) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126 )
Interacting Genes		2 interacting genes: ADAM22 CLIC6	9 interacting genes: APP DYRK1A DYRK3 EPS8 LCOR LGI1 RAC2 YWHAB YWHAZ
Entrez ID		9211	53616
HPRD ID		05216	04751
Ensembl ID		ENSG00000108231	ENSG00000008277
Uniprot IDs		A0A0S2Z4S7 A0A0S2Z4X3 A0A0S2Z5G1 A0A1B0GUD3 O95970	H7C3I4 Q08AL8 Q9P0K1
PDB IDs		5Y2Z 5Y30 5Y31 8HPY 8HQ1 8HQ2 8Y6B	3G5C 5Y2Z 5Y31 7CQF 8HPY 8HQ1 8HQ2 8Y6B
GO Terms Enriched among Interactors		Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding D2 Dopamine Receptor Binding Methyl-branched Fatty Acid Metabolic Process Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Fatty Acid Alpha-oxidation Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Long-chain Fatty Acid Import Into Cell Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Lipid Import Into Cell Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transmembrane Transporter Activity Bile Acid Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Bile Acid Metabolic Process Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Transport Chloride Channel Complex	Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Localization To Nucleus Protein Serine/threonine/tyrosine Kinase Activity Amyloid-beta Complex Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Neuron Recognition Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Histone H3T45 Kinase Activity Protein Sequestering Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Intracellular Signaling Cassette Protein Phosphorylation Adult Locomotory Behavior Regulation Of Supramolecular Fiber Organization Regulation Of Protein Localization Phosphorylation Actin Filament Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Synaptic Target Recognition PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Cell Recognition Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Axon Midline Choice Point Recognition Positive Regulation Of Chemotaxis Dendrite Endosome To Plasma Membrane Transport Vesicle