BUB3 and RPL37A

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		BUB3	RPL37A
Name		BUB3 mitotic checkpoint protein	ribosomal protein L37a
Structure		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex	Nucleus Cytoplasm Cytosol Ribosome Focal Adhesion Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Ubiquitin Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Chromosome Segregation	Cytoplasmic Translation Translation
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
GWAS		Body mass index ( 28892062 ) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416 ) Left-handedness ( 32989287 ) Lung volume ( 34128465 ) Menopause (age at onset) ( 24045676 ) Right lateral prefrontal cortical growth ( 29682794 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Extremely high intelligence ( 29520040 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) White matter integrity (fractional anisotropy) ( 32358547 )
Interacting Genes		20 interacting genes: ANXA1 BUB1 BUB1B CEBPA CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 REXO4 RPL37A SUGT1 THRA TOP1 UBA1 WBP4	10 interacting genes: APP BUB3 CTPS2 FBXO7 FOXP1 IFNGR2 LRIF1 MAGEA6 NKX3-1 PRMT1
Entrez ID		9184	6168
HPRD ID		04761	17997
Ensembl ID		ENSG00000154473	ENSG00000197756
Uniprot IDs		A0A140VJF3 O43684	P61513
PDB IDs		Not available	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7XNX 7XNY 8A3D 8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
GO Terms Enriched among Interactors		Nucleoplasm Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway NAD+-protein-serine ADP-ribosyltransferase Activity Nucleus NuRD Complex DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Sin3-type Complex Protein Lysine Delactylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Cell Fate Specification Fungiform Papilla Formation Chromatin Remodeling Meiotic Sister Chromatid Cohesion, Centromeric NF-kappaB Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Chromatin Binding Hair Follicle Placode Formation Histone Deacetylase Binding Histone Deacetylase Complex Circadian Rhythm Macromolecule Metabolic Process Regulation Of Cell Fate Commitment Regulation Of Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Response To Temperature Stimulus Chromatin Organization Chromosome Organization Positive Regulation Of Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Protein Auto-ADP-ribosylation Positive Regulation Of Developmental Process Meiotic Sister Chromatid Cohesion Cytosol NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of Stem Cell Population Maintenance Response To Steroid Hormone NAD+-protein-aspartate ADP-ribosyltransferase Activity Protein Lysine Deacetylase Activity Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Stem Cell Differentiation Eyelid Development In Camera-type Eye Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides	Macrophage Activation Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Myeloid Leukocyte Activation Regulation Of Mitotic Cell Cycle Leukocyte Activation Microglial Cell Activation Cell Activation Leukocyte Activation Involved In Inflammatory Response GATOR1 Complex Binding Response To Testosterone Positive Regulation Of Androgen Secretion MADS Box Domain Binding Bub1-bub3 Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Myeloid Cell Development Negative Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Interleukin-1 Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Chemokine Production Negative Regulation Of Transcription By RNA Polymerase II Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Negative Regulation Of Macromolecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Nucleus Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of Interleukin-1 Beta Production