WDR20 and LIG4

Number of citations: 93 (PubMedID 22990118)
Data Source: BioGRID (two hybrid)

		WDR20	LIG4
Name		WD repeat domain 20	DNA ligase 4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function	Protein Binding Deubiquitinase Activator Activity	Nucleotide Binding Magnesium Ion Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding AMP Binding Ligase Activity Metal Ion Binding
	Biological Process	None	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Ionizing Radiation Response To Gamma Radiation Neurogenesis T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Stem Cell Proliferation Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining DN2 Thymocyte Differentiation Positive Regulation Of Chromosome Organization
Pathways		Ub-specific processing proteases	2-LTR circle formation Nonhomologous End-Joining (NHEJ)
Diseases		None	DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Plateletcrit ( 32888494 ) Red cell distribution width ( 27863252 28957414 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )	Attention deficit hyperactivity disorder and conduct disorder ( 18951430 ) Irritable bowel syndrome ( 29626450 )
Interacting Genes		3 interacting genes: LIG4 USP12P1 ZDHHC17	103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATOSA ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT
Entrez ID		91833	3981
HPRD ID		11679	03500
Ensembl ID		ENSG00000140153	ENSG00000174405
Uniprot IDs		A0A088AWN2 B3KPG5 Q5JPH5 Q8TBZ3	A0A0C4DGV9 A8K8Q4 P49917
PDB IDs		5K19 5K1C 6JLQ	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG 7D9K 7D9Y 7LSY 7LT3 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB
GO Terms Enriched among Interactors		Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Protein-cysteine S-myristoyltransferase Activity Nucleotide-excision Repair, DNA Gap Filling Protein-cysteine S-stearoyltransferase Activity DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Double-strand Break Repair Via Classical Nonhomologous End Joining Lymphoid Progenitor Cell Differentiation Single Strand Break Repair AMP Binding Regulation Of Neurotrophin TRK Receptor Signaling Pathway Golgi-associated Vesicle Membrane Cellular Response To Lithium Ion Response To Lithium Ion V(D)J Recombination Lipoprotein Transport Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Protein-cysteine S-palmitoyltransferase Activity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Response To X-ray Protein Lipidation Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Fibroblast Proliferation Somatic Cell DNA Recombination T Cell Differentiation In Thymus Somatic Diversification Of Immunoglobulins Response To Gamma Radiation Positive Regulation Of Fibroblast Proliferation Double-strand Break Repair Via Nonhomologous End Joining B Cell Activation Involved In Immune Response Somatic Stem Cell Population Maintenance	Histone H2AXS139 Kinase Activity Respiratory Electron Transport Chain Electron Transport Chain Aerobic Respiration Aerobic Electron Transport Chain Cellular Respiration Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining ATP Synthesis Coupled Electron Transport Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Repair Generation Of Precursor Metabolites And Energy Macromolecule Metabolic Process V(D)J Recombination Proton Transmembrane Transport Respiratory Chain Complex I DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Protein Localization To Site Of Double-strand Break Energy Derivation By Oxidation Of Organic Compounds Extracellular Exosome Response To Ionizing Radiation DNA Metabolic Process Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Telomere Maintenance Positive Regulation Of Telomerase Catalytic Core Complex Assembly Cytochrome-c Oxidase Activity Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Chromosome Organization Chromosome Organization Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Proton Motive Force-driven ATP Synthesis ATP Metabolic Process NADH Dehydrogenase Complex Assembly Mitochondrial Respiratory Chain Complex I Assembly Response To Radiation DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Positive Regulation Of Telomere Maintenance Regulation Of Protein Metabolic Process RNA Binding NADH Dehydrogenase (ubiquinone) Activity Regulation Of Cellular Response To Heat DNA Recombination