IL1RL1 and TMED1

Number of citations: 0 (PubMedID 8621446)
Data Source: HPRD (in vivo)

		IL1RL1	TMED1
Name		interleukin 1 receptor like 1	transmembrane p24 trafficking protein 1
Structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Protein Binding Hydrolase Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Signaling Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of T-helper 1 Type Immune Response Inflammatory Response Immune Response Signal Transduction Response To Wounding Macrophage Differentiation Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Inflammatory Response	Immune System Process Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Signal Transduction Cell-cell Signaling Protein Transport Innate Immune Response
Pathways		PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling	None
GWAS		Adult asthma ( 30578877 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Allergic rhinitis ( 30013184 31361310 ) Allergic sensitization ( 30013184 23817571 ) Allergy ( 27182965 ) Asthma ( 27182965 30929738 29273806 26620591 31361310 31619474 34103634 21804549 23028483 32296059 31959851 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 29273806 31036433 ) Asthma (moderate or severe) ( 30552067 ) Asthma (time to onset) ( 27130862 ) Asthma and hay fever ( 24388013 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 26482879 23042114 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Celiac disease ( 18311140 20190752 ) Childhood asthma with severe exacerbations ( 33328473 ) Crohn's disease ( 21102463 28067908 ) Delirium ( 29631748 ) Eosinophil count ( 29403010 32888494 19198610 ) Eosinophil percentage of white cells ( 32888494 ) FEV1 ( 30804560 ) Inflammatory bowel disease ( 28067908 23128233 ) Lung function (FEV1/FVC) ( 30804560 ) Nasal polyps ( 30643255 ) Neutrophil percentage of white cells ( 32888494 ) Primary biliary cholangitis ( 26394269 ) Self-reported allergy ( 23817569 ) Serum protein levels (sST2) ( 23999434 ) Waist circumference ( 23966867 )	No GWAS studies recorded
Interacting Genes		18 interacting genes: APP ASGR2 CLEC12B CLEC2D CLEC7A CREB3L1 GPR152 GPR42 HRAS IL33 MCFD2 MYD88 SIGLEC12 SLC38A1 TIRAP TMED1 TSPAN18 YIPF6	6 interacting genes: F2RL1 GPR37 IL1RL1 LTB4R2 SEC23B SMAD3
Entrez ID		9173	11018
HPRD ID		03123	05653
Ensembl ID		ENSG00000115602	ENSG00000099203
Uniprot IDs		Q01638	Q13445
PDB IDs		4KC3	7RRM
GO Terms Enriched among Interactors		Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Vesicle-mediated Transport Defense Response To Protozoan Positive Regulation Of JNK Cascade Response To Protozoan Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon Production Response To Molecule Of Fungal Origin Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response To Other Organism Positive Regulation Of Cytokine Production Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of JNK Cascade Positive Regulation Of Interleukin-23 Production Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Plasma Membrane Regulation Of Interleukin-23 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Interleukin-1 Production Defense Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Immune Response-regulating Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Leukocyte Migration Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Innate Immune Response Response To Yeast Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Regulation Of Interleukin-8 Production Defense Response To Symbiont MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress	Positive Regulation Of Positive Chemotaxis Proteinase-activated Receptor Activity Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Regulation Of Interleukin-1 Production Regulation Of Type II Interferon Production Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium G Protein-coupled Receptor Activity Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Interleukin-1 Beta Production Neuropeptide Signaling Pathway Prosaposin Receptor Activity G Protein-coupled Peptide Receptor Activity Sterol Response Element Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Ameboidal-type Cell Migration Paraxial Mesoderm Morphogenesis Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Interleukin-33 Binding Interleukin-33 Receptor Activity Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Regulation Of Wound Healing Positive Regulation Of Chemotaxis Myeloid Leukocyte Differentiation Positive Regulation Of Killing Of Cells Of Another Organism Regulation Of Lung Blood Pressure Leukotriene Signaling Pathway Cell-cell Junction Organization Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Cytoskeleton Organization Mature Conventional Dendritic Cell Differentiation Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Signal Transduction Regulation Of Response To Wounding Regulation Of Blood Pressure Thrombin-activated Receptor Activity Positive Regulation Of Dopamine Metabolic Process Pericardium Development Mesoderm Morphogenesis