ACY3 and RARG

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ACY3	RARG
Name		aminoacylase 3	retinoic acid receptor gamma
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Membrane RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Aminoacylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	None	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Chondrocyte Development Glandular Epithelial Cell Development Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Growth Regulation Of DNA-templated Transcription Apoptotic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Size Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Programmed Cell Death Cell Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Reproductive Structure Development Gland Development Canonical Wnt Signaling Pathway Limb Development Face Development Bone Development Bone Morphogenesis Epithelium Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cartilage Development Harderian Gland Development Cellular Response To Retinoic Acid Stem Cell Proliferation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Stem Cell Proliferation
Pathways		Aflatoxin activation and detoxification	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		None	Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin SR11254 BMS-181156 CD564 Dodecyl-Alpha-D-Maltoside BMS184394 Palovarotene LGD-1550 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid Trifarotene
GWAS		Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Serum metabolite levels ( 24625756 33031748 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Waist circumference adjusted for body mass index ( 34021172 )	Anthracycline-induced cardiotoxicity in childhood cancer ( 26237429 ) Cardiorespiratory fitness (800m run time) ( 32572135 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 )
Novel Interactors		None recorded	2 novel interactors: NEK9 PRIM1
Interacting Genes		21 interacting genes: AAMDC ARF5 ASPA CYSRT1 DDIT4L GORASP2 INCA1 KRTAP10-3 KRTAP10-8 KRTAP15-1 KRTAP26-1 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 PTGER4 RARG RRAS	33 interacting genes: ACY3 ARID1A BBS4 HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 MYF5 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 PRKAR1B PSMC5 RHPN2 RXRA RXRB RXRG S100A3 SMAD3 SMARCD3 SPHK1 TNIP1 ZNF576
Entrez ID		91703	5916
HPRD ID		12422	01573
Ensembl ID		ENSG00000132744	ENSG00000172819
Uniprot IDs		E9PRA7 Q96HD9	A8K3H3 B7Z4B4 F1D8P1 P13631
PDB IDs		Not available	1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24 6FX0
GO Terms Enriched among Interactors		Intermediate Filament	Nuclear Receptor Binding Chromatin Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulator Complex Retinoic Acid-responsive Element Binding Regulation Of Gene Expression Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleosome Disassembly Protein-DNA Complex Disassembly Nuclear Steroid Receptor Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Nuclear Thyroid Hormone Receptor Binding DNA Binding Sequence-specific DNA Binding Positive Regulation Of Developmental Process Regulation Of Response To Nutrient Levels Regulation Of Metabolic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of Bone Mineralization Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Primary Metabolic Process Positive Regulation Of Myoblast Differentiation Somitogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II