PCSK7 and CSDE1

Number of citations: 0 (PubMedID 11051545)
Data Source: HPRD (in vivo)

		PCSK7	CSDE1
Name		proprotein convertase subtilisin/kexin type 7	cold shock domain containing E1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Trans-Golgi Network Endomembrane System Membrane	P-body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex MCRD-mediated MRNA Stability Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RNA Stem-loop Binding LncRNA Binding RISC Complex Binding
	Biological Process	Proteolysis Protein Processing Peptide Hormone Processing	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Positive Regulation Of Translation ERK1 And ERK2 Cascade CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation
Pathways		Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	None
GWAS		Cardiovascular disease risk factors ( 21943158 ) HDL cholesterol ( 24507774 31170924 ) Iron status biomarkers ( 21149283 ) Refractive error ( 32231278 ) Triglyceride levels ( 26763881 ) Triglycerides ( 24507774 )	Autism ( 24189344 )
Interacting Genes		7 interacting genes: CSDE1 HNRNPD HSPA5 PABPC1 PMCH SYNCRIP TRIM54	18 interacting genes: ARHGAP5 C11orf68 CEBPA ERBB2 FAM9B FOXP1 HID1 HNRNPD NEIL3 PABPC1 PCSK7 PSMG1 RNF10 SNW1 STT3A SYNCRIP WBP4 WNK1
Entrez ID		9159	7812
HPRD ID		05339	15949
Ensembl ID		ENSG00000160613	ENSG00000009307
Uniprot IDs		Q16549	O75534
PDB IDs		Not available	1WFQ 1X65 2YTV 2YTX 2YTY
GO Terms Enriched among Interactors		MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Cytoplasmic Translation MRNA Stabilization Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability CRD-mediated MRNA Stability Complex Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Catabolic Process Regulation Of Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleic Acid Binding Post-transcriptional Regulation Of Gene Expression RNA Catabolic Process Regulation Of Protein Metabolic Process MRNA Binding Nucleobase-containing Compound Catabolic Process Macromolecule Catabolic Process Hepatocyte Dedifferentiation Ribonucleoprotein Complex Cellular Response To Putrescine Regulation Of Protein Folding In Endoplasmic Reticulum Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Catalytic Step 2 Spliceosome Negative Regulation Of Gene Expression Cytoplasmic Stress Granule Positive Regulation Of Gene Expression Circadian Regulation Of Translation Cerebellum Structural Organization Negative Regulation Of Synaptic Transmission, Dopaminergic Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MRNA Metabolic Process	MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Catalytic Step 2 Spliceosome Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Cytoplasmic Translation RNA Splicing, Via Transesterification Reactions Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Translation MRNA Stabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of MRNA Catabolic Process RNA Stabilization Nucleic Acid Binding RNA Splicing Proteasome Binding Response To Ketone Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Motor Neuron Axon Guidance Nuclear Androgen Receptor Binding MRNA Processing Regulation Of Protein Metabolic Process Regulation Of Biological Quality Nuclear Matrix Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Skeletal Muscle Hypertrophy U2-type Catalytic Step 2 Spliceosome Proteasome Core Complex Assembly Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Protein Localization To Vacuolar Membrane MCM Complex Binding