CTDP1 and ELP2

Number of citations: 35 (PubMedID 11818576)
Data Source: BioGRID (pull down)

		CTDP1	ELP2
Name		CTD phosphatase subunit 1	elongator acetyltransferase complex subunit 2
Structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytoskeleton Midbody Protein-containing Complex Spindle Midzone	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	TFIIF-class Transcription Factor Complex Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Tat Protein Binding	RNA Polymerase II Complex Binding Protein Kinase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Exit From Mitosis Host-mediated Activation Of Viral Transcription Cell Division Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development	TRNA Wobble Uridine Modification Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Regulation Of Translation TRNA Processing Regulation Of Receptor Signaling Pathway Via JAK-STAT
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	HATs acetylate histones
GWAS		Adverse response to drug ( 30420678 ) Cerebrospinal P-tau181p levels ( 28247064 ) Metabolite levels ( 23823483 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 32888494 ) Schizophrenia ( 23212062 ) Smoking initiation (ever regular vs never regular) ( 30679032 )	Serum metabolite levels ( 33031748 )
Interacting Genes		41 interacting genes: AKT1 CDK7 CDK8 CDK9 CSNK2A1 CSNK2A2 CSNK2B E2F1 ELP2 ELP3 ERH GTF2F1 INTS1 INTS3 INTS6 INTS7 INTS8 MED1 MED15 MED16 MED17 MED23 MED24 MED25 MED26 MED4 MED6 MED7 MED8 NDRG2 POLR2A POLR2B PRKDC PRMT5 SNRNP70 SNRPB STK38 TCEA1 UPP1 USP7 WDR77	8 interacting genes: CTDP1 ELP1 ELP6 JAK1 JAK2 STAT1 STAT3 STAT5B
Entrez ID		9150	55250
HPRD ID		05377	15443
Ensembl ID		ENSG00000060069	ENSG00000134759
Uniprot IDs		Q9Y5B0	Q6IA86
PDB IDs		1J2X 1ONV 2K7L	8PTX 8PTY 8PTZ 8PU0
GO Terms Enriched among Interactors		Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly RNA Metabolic Process Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Nucleoplasm Nucleic Acid Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Nucleobase-containing Compound Biosynthetic Process Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Coregulator Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-templated Transcription Elongation Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Vitamin D Receptor Binding DNA-templated Transcription Nuclear RNA Surveillance Positive Regulation Of Biosynthetic Process INTAC Complex RNA Surveillance DNA-templated Transcription Initiation	Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Type II Interferon-mediated Signaling Pathway Interleukin-6-mediated Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Erythrocyte Differentiation Response To Cytokine Response To Peptide Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Elongator Holoenzyme Complex Interferon-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway RNA Metabolic Process Erythropoietin-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Cellular Response To Hormone Stimulus Interleukin-2-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation T-helper 17 Cell Lineage Commitment Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Natural Killer Cell Proliferation Nuclear Glucocorticoid Receptor Binding Regulation Of Skeletal Muscle Cell Proliferation TRNA Wobble Uridine Modification Cellular Response To Cytokine Stimulus RNA Polymerase II Transcription Regulator Complex T-helper Cell Lineage Commitment Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Homotypic Cell-cell Adhesion Photoreceptor Cell Differentiation Regulation Of Macromolecule Biosynthetic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Primary Metabolic Process Alpha-beta T Cell Lineage Commitment Positive Regulation Of Cytokine Production