HGS and RSU1

Number of citations: 84 (PubMedID 19019082)
Data Source: BioGRID (pull down)

		HGS	RSU1
Name		hepatocyte growth factor-regulated tyrosine kinase substrate	Ras suppressor protein 1
Structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Multivesicular Body Membrane ESCRT-0 Complex Extracellular Exosome Phagocytic Vesicle Lumen	Cytosol Focal Adhesion Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Protein Domain Specific Binding Phosphatidylinositol Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Targeting To Lysosome Signal Transduction Negative Regulation Of Cell Population Proliferation Membrane Invagination Positive Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Transport Endosomal Transport Macroautophagy Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Receptor Internalization Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Localization To Membrane Membrane Fission Positive Regulation Of Exosomal Secretion	Signal Transduction Ras Protein Signal Transduction Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of GTPase Activity
Pathways		EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion RHOBTB3 ATPase cycle	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs		Citric acid	None
GWAS		Eye color traits ( 20463881 ) Refractive error ( 32231278 )	Adult body size ( 32376654 ) Bone mineral content ( 31790847 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Initial alcohol sensitivity ( 30276832 ) Major depressive disorder ( 29317602 ) Metabolite levels ( 23823483 ) Nicotine dependence symptom count ( 25555482 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave. ( 28394258 ) Urinary albumin excretion ( 21355061 ) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737 )
Interacting Genes		328 interacting genes: ABI2 ACLY ACOT11 ACTN3 ADRA2C AHCYL1 AKAP8L ANKRD55 ANTKMT APC APLP2 APP ARFIP2 ARL6IP1 ARMC7 ASB12 ATN1 ATP1A1 ATP2A2 ATXN1L BBC3 BCAS2 BEGAIN BFSP2 BICRAL BLOC1S1 BORCS6 BRINP3 BSG C1orf94 C20orf173 C3orf36 CASK CBS CCDC136 CCDC196 CCDC33 CCND3 CDR2 CDSN CEACAM6 CEP55 CEP57L1 CEP63 CEP68 CFAP68 CIMIP2A CLTC COG8 CRMP1 CRX CSNK2A1 CSTF2 CSTF2T CTTNBP2NL CYB5R2 DAAM2 DAZAP2 DCTN2 DECR1 DEUP1 DGCR6 DLG4 DNAAF19 DSN1 DTX2 DYDC1 EFHC2 EGFL7 EGFR EHMT2 EIF3F EPS15 ESRRG EXOC3L1 EXOC5 EXOC7 EXOC8 EYA2 FAM168A FAM185A FANCG FBN1 FCHSD2 FIGN FLOT1 FLOT2 FNDC11 FOXD4L1 FOXI1 FSD2 FTCD GATC GFAP GFI1B GGA2 GKAP1 GOLGA2 GOLGA6L9 GOLGA7B GUCA1C HAP1 HAUS1 HNRNPDL HNRNPM HSF4 HSFY1 HSPA8 ICA1L IFNA16 IFT74 IL2RB IL4R ILKAP ING5 INTS4 IPO4 JAKMIP2 JMJD7 KIAA0753 KIAA0825 KLF4 KRT13 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT26 KRT27 KRT3 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT6A KRT75 KRT76 KRT82 KRT86 KRTAP19-5 KRTAP26-1 KRTAP7-1 LASP1 LDOC1 LINC00265 LITAF LMO1 LMO4 LRRC61 LURAP1 LYST MAGEB4 MAGED1 MAP3K1 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED21 MED22 MED25 MED30 MED4 MED7 MEIS3 MEST MET METTL27 MIF4GD MKNK1 MKRN3 MRFAP1L1 MTHFD1L NADSYN1 NDC80 NDUFB10 NEDD4 NEDD8 NEFL NF2 NFYC NMI NPAS2 NUP54 NUP62 NUTM2F ODAM OIP5 OSBPL5 P4HA3 PAK1 PAX5 PAX6 PEF1 PELP1 PFKM PIK3R1 PITX1 PKNOX2 PLA2G10 PLAAT1 PLCD1 PLD3 PLEKHB2 PMEPA1 PNMA1 POGZ POU2AF1 POU6F2 PPP1R16A PPP1R7 PPP2R3B PRR22 PRR5 PSMB11 PSMB4 PTCD3 RASSF4 RBCK1 RFC2 RFX6 RHOBTB3 RINT1 RNF4 RPRD1A RPS3A RSPO4 RSU1 RUNX1 SAPCD1 SAXO4 SCAMP3 SCRN1 SCT SDS SERGEF SERTAD3 SF3B3 SHANK3 SMAD2 SMAD3 SMAD5 SMARCB1 SNAP25 SNX1 SNX5 SNX7 SORBS3 SPATA12 SPC25 SPIRE2 SPMIP6 SS18L1 STAM STAM2 STK32C STMN3 STX11 STXBP1 SUMO1 SUN2 SYK TADA2A TASOR2 TBX19 TCP11L2 TEKT1 TEKT5 TFG TIMM10B TIMMDC1 TJP2 TLE5 TMCC2 TOM1L1 TP53BP1 TRAF1 TRAF4 TRAK1 TRAP1 TRIM10 TRIM17 TRIM23 TRIM27 TRIM54 TRIM69 TRIM73 TRIML2 TSC1 TSG101 TUBB TUBB2A UBA1 UBA52 UBAP2 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 UBQLNL UBXN11 USHBP1 USP54 VGLL3 VMP1 VPS37A VPS37B VPS37C VPS37D VPS52 WASHC1 WWP2 YPEL3 ZNF302 ZNF34 ZNF430 ZNF44	5 interacting genes: APP GSK3B HGS LIMS1 RAF1
Entrez ID		9146	6251
HPRD ID		05085	01551
Ensembl ID		ENSG00000185359	ENSG00000148484
Uniprot IDs		A0A0S2Z4R4 O14964	Q15404
PDB IDs		2D3G 3F1I 3OBQ 3ZYQ 4AVX	7D2S 7D2T 7D2U 7LT8 7LT9
GO Terms Enriched among Interactors		Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Protein Binding Structural Molecule Activity Organelle Organization Epithelial Cell Differentiation Supramolecular Fiber Organization Cytoskeleton Organization Cytoskeleton Morphogenesis Of An Epithelium Tissue Morphogenesis Anatomical Structure Morphogenesis Cellular Localization Cytosol Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Ubiquitin Protein Ligase Binding Intracellular Transport Intracellular Protein Localization Establishment Of Protein Localization Axonemal A Tubule Inner Sheath Microtubule-based Process Protein Transport Establishment Of Protein Localization To Vacuole Structural Constituent Of Cytoskeleton Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Establishment Of Localization In Cell Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway ESCRT I Complex Protein Localization To Vacuole Multivesicular Body Assembly Multivesicular Body Organization Endosomal Transport Endosome Membrane Multivesicular Body Sorting Pathway Identical Protein Binding Epidermis Development Modification-dependent Protein Catabolic Process Late Endosome To Vacuole Transport Viral Budding Protein Tag Activity Core Mediator Complex Exocyst Organelle Localization	Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Neuron Projection Organization Positive Regulation Of Gene Expression Response To Amyloid-beta Positive Regulation Of Biosynthetic Process Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Intracellular Signal Transduction Cellular Response To Amyloid-beta Regulation Of Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell-matrix Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Glial Cell Development Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Amylin Binding Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Calcium-mediated Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Regulation Of Catalytic Activity Epithelial To Mesenchymal Transition Regulation Of Microtubule Anchoring At Centrosome Insulin Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchymal Cell Differentiation Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Generation Of Precursor Metabolites And Energy Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development