FAAP24 and EME2

Number of citations: 0 (PubMedID 17289582)
Data Source: BioGRID (pull down)

		FAAP24	EME2
Name		FA core complex associated protein 24	essential meiotic structure-specific endonuclease subunit 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Chromosome, Telomeric Region Nucleus Nuclear Replication Fork Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding	DNA Binding Nuclease Activity DNA Endonuclease Activity Protein Binding Crossover Junction DNA Endonuclease Activity Enzyme-substrate Adaptor Activity
	Biological Process	DNA Repair DNA Damage Response Interstrand Cross-link Repair	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Replication Fork Processing Mitotic Intra-S DNA Damage Checkpoint Signaling Resolution Of Mitotic Recombination Intermediates
Pathways		Fanconi Anemia Pathway PKR-mediated signaling	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		5 interacting genes: APP EME2 FANCM RBBP6 TERT	5 interacting genes: FAAP24 FANCM MEOX2 MUS81 UBC
Entrez ID		91442	197342
HPRD ID		14547	16859
Ensembl ID		ENSG00000131944	ENSG00000197774
Uniprot IDs		A0A0S2Z5V6 K7EKQ4 Q9BTP7	A4GXA9
PDB IDs		2LYH 2M9M 2M9N 4BXO 4M6W	7F6L
GO Terms Enriched among Interactors		DNA Metabolic Process Resolution Of Meiotic Recombination Intermediates DNA Recombination Replication Fork Processing Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Response To Stress Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Mitotic Cell Cycle TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Meiosis I Cell Cycle Process Protein-folding Chaperone Binding Cellular Response To Stress Telomere Maintenance Acetylcholine Receptor Activator Activity Positive Regulation Of Mitotic Cell Cycle Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Telomere Organization Nuclease Activity PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Localization To Nucleus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Damage Response Nucleic Acid Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity Response To Norepinephrine DNA Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus	FANCM-MHF Complex Fanconi Anaemia Nuclear Complex Resolution Of Meiotic Recombination Intermediates Replication Fork Processing Interstrand Cross-link Repair Meiosis I Cell Cycle Process DNA Repair DNA Endonuclease Activity, Producing 3'-phosphomonoesters 3'-flap Endonuclease Activity Nuclease Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process DNA Binding Double-strand Break Repair Via Synthesis-dependent Strand Annealing DNA Damage Response Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Endodeoxyribonuclease Complex Somite Specification Positive Regulation Of Protein Monoubiquitination Resolution Of Mitotic Recombination Intermediates Four-way Junction Helicase Activity Double-strand Break Repair Regulation Of Protein Monoubiquitination DNA Recombination Response To DNA Damage Checkpoint Signaling Chromatin Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Osteoblast Proliferation Double-strand Break Repair Via Break-induced Replication 3'-5' DNA Helicase Activity Protein Tag Activity Segment Specification Somite Development Four-way Junction DNA Binding Mitotic Intra-S DNA Damage Checkpoint Signaling Nuclear Replication Fork Cellular Response To Stress DNA Endonuclease Activity Nucleus Chromatin Binding DNA Catabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Replication Fork Homologous Recombination Nucleoplasm