CD1A and KCTD5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CD1A	KCTD5
Name		CD1a molecule	potassium channel tetramerization domain containing 5
Structure
GO Annotations	Cellular Component	Extracellular Space Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Membrane Raft	Nucleus Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Lipopeptide Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding Cullin Family Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Immune System Process Immune Response Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Homooligomerization
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	None
Drugs		Antithymocyte immunoglobulin (rabbit)	None
GWAS		Change in neurofilament light levels ( 31295725 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: B2M DGAT1 KCTD5 UBTD1	7 interacting genes: CD1A EP300 GIT2 GORASP2 NEK6 NXF1 PRKAB2
Entrez ID		909	54442
HPRD ID		01776	13768
Ensembl ID		ENSG00000158477	ENSG00000167977
Uniprot IDs		P06126	Q9NXV2
PDB IDs		1ONQ 1XZ0 4X6C 4X6D 4X6E 4X6F 5J1A 6NUX 7KOZ 7KP0 7KP1 7RYM 7RYN 7RYO 7SH4	3DRX 3DRY 3DRZ 8U7Z 8U80 8U81 8U82 8U83 8U84
GO Terms Enriched among Interactors		Cellular Response To Iron(III) Ion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Protein Homooligomerization Negative Regulation Of Forebrain Neuron Differentiation Regulation Of Forebrain Neuron Differentiation Response To Iron(III) Ion Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Negative Regulation Of Iron Ion Transport Diacylglycerol O-acyltransferase Activity 2-acylglycerol O-acyltransferase Activity Retinol O-fatty-acyltransferase Activity Cellular Response To Nicotine HFE-transferrin Receptor Complex Regulation Of Iron Ion Transport MHC Class I Protein Complex MHC Class I Peptide Loading Complex Cellular Response To Iron Ion Early Endosome Lumen Protein Complex Oligomerization Protein-containing Complex Organization Peptide Antigen Assembly With MHC Class I Protein Complex Protein-containing Complex Assembly Monoacylglycerol Biosynthetic Process Transferrin Transport Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Cellular Senescence Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Identical Protein Binding Fatty Acid Homeostasis Triglyceride Biosynthetic Process MHC Class II Protein Complex Binding T Cell Mediated Cytotoxicity Multicellular Organismal-level Iron Ion Homeostasis Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Long-chain Fatty-acyl-CoA Metabolic Process Diacylglycerol Metabolic Process O-acyltransferase Activity Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Cullin Family Protein Binding Protein Refolding Positive Regulation Of T Cell Cytokine Production Antigen Processing And Presentation Of Endogenous Antigen Amyloid Fibril Formation Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Response To Iron Ion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I	Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Exogenous Lipid Antigen Binding Endogenous Lipid Antigen Binding Negative Regulation Of Protein Oligomerization