LDB2 and RILP

Number of citations: 0 (PubMedID 18330356)
Data Source: BioGRID (two hybrid)

		LDB2	RILP
Name		LIM domain binding 2	Rab interacting lysosomal protein
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Plasma Membrane Cell Leading Edge	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Protein-containing Complex Ciliary Basal Body
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding	Protein Binding Small GTPase Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Hair Follicle Development Nervous System Development Epithelial Structure Maintenance Regulation Of Cell Migration Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Transcription By RNA Polymerase II	Endosome To Lysosome Transport Protein Transport Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Protein Catabolic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Cilium Assembly Intralumenal Vesicle Formation
Pathways		None	MHC class II antigen presentation
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429 ) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292 ) Liver fibrosis (total hepatic collagen content) ( 32953199 ) Number of sexual partners ( 30643258 ) QT interval ( 23534349 ) Rhegmatogenous retinal detachment ( 23585552 ) Systemic juvenile idiopathic arthritis ( 27927641 ) Waist circumference ( 28552196 )	No GWAS studies recorded
Interacting Genes		31 interacting genes: C14orf119 CETN3 DGCR6L EGLN3 EPM2AIP1 EXOC3L1 GGACT GRIK1 HDAC7 ISL1 LHX3 LHX4 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LNX1 NTAQ1 PSMB1 RASIP1 RILP RLIM SDCBP SMARCD1 SSBP2 SSBP3 SSBP4 TSNAX TTC19	12 interacting genes: KPNA2 LDB2 RAB34 RAB7A RCHY1 SNF8 VPS11 VPS16 VPS18 VPS36 VPS39 VPS41
Entrez ID		9079	83547
HPRD ID		16022	09706
Ensembl ID		ENSG00000169744	ENSG00000167705
Uniprot IDs		B7Z6D0 E9PFI4 G5E9Y7 O43679	Q96NA2
PDB IDs		Not available	1YHN
GO Terms Enriched among Interactors		Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord Regulation Of Transcription By RNA Polymerase II Medial Motor Column Neuron Differentiation Neuron Fate Specification DNA-binding Transcription Factor Binding Motor Neuron Axon Guidance Nucleus Neuron Projection Guidance Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Neuron Differentiation Axon Guidance Positive Regulation Of Transcription By RNA Polymerase II Single-stranded DNA Binding Transcription Regulator Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Transcription Coactivator Activity Spinal Cord Association Neuron Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cell Fate Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Metal Ion Binding Spinal Cord Motor Neuron Differentiation Regulation Of Metabolic Process Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Regulation Of Gene Expression Pituitary Gland Development Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Neuron Projection Development Interleukin-5 Receptor Complex Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Dorsal Spinal Cord Interneuron Anterior Axon Guidance Gamma-glutamylaminecyclotransferase Activity Positive Regulation Of Macromolecule Metabolic Process Central Nervous System Neuron Differentiation Transcription Coregulator Binding	Vesicle Organization Late Endosome Membrane Vacuolar Transport Organelle Membrane Fusion Vesicle Fusion Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Endosome To Lysosome Transport Organelle Fusion Autophagy Late Endosome Membrane Fusion Intracellular Protein Transport Membrane Organization Protein Transport Lysosomal Transport Endosome Membrane Establishment Of Protein Localization Cellular Localization Vesicle-mediated Transport Endosome Intracellular Transport Intracellular Protein Localization Lysosome CORVET Complex AP-3 Adaptor Complex Establishment Of Localization In Cell Establishment Of Protein Localization To Vacuole Lysosomal Membrane Clathrin-coated Vesicle Organelle Organization Endosome Organization Protein Localization To Vacuole Catabolic Process Lysosomal HOPS Complex Endosomal Transport ESCRT II Complex Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Organelle Vesicle Tethering Complex Macroautophagy Vacuole Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Catabolic Process Cytoplasmic Vesicle Endocytic Recycling Autophagosome Phagosome Maturation Membrane Docking