CLDN8 and PKMYT1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CLDN8	PKMYT1
Name		claudin 8	protein kinase, membrane associated tyrosine/threonine 1
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Anchoring Junction	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Meiotic Cell Cycle Negative Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Pathways		Tight junction interactions	Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint
Drugs		None	Fostamatinib
GWAS		Response to statin therapy ( 20339536 )	Metabolic syndrome ( 20694148 )
Interacting Genes		12 interacting genes: ADAM32 ARL13B CLEC17A ERGIC3 KASH5 OPRM1 PKMYT1 SMIM3 SYNE4 TJP1 TMEM80 TRARG1	24 interacting genes: ABHD16A BCL2 CCNB1 CD3E CD79A CDK1 CLDN8 ELOVL4 FATE1 LIME1 LRRC25 MAPK10 MAPK8 PIN1 PLK1 RETREG3 SLC10A1 SLC30A8 SLC61A1 SLC71A2 STEAP3 TMEM101 TMEM229B TMX2
Entrez ID		9073	9088
HPRD ID		10835	03920
Ensembl ID		ENSG00000156284	ENSG00000127564
Uniprot IDs		A0A0K0K1I9 P56748	Q0IJ49 Q99640
PDB IDs		Not available	3P1A 5VCV 5VCW 5VCX 5VCY 5VCZ 5VD0 5VD1 5VD3 8D6C 8D6D 8D6E 8D6F 8WJY 8ZTX 8ZU2 8ZUD 8ZUL
GO Terms Enriched among Interactors		Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Nuclear Outer Membrane	Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Cyclin B1-CDK1 Complex Protein Localization To Site Of Double-strand Break JUN Kinase Activity Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport B Cell Receptor Complex Immune Response-regulating Signaling Pathway Mitotic Cell Cycle Phase Transition Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Cycle G2/M Phase Transition Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Striated Muscle Cell Development Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Membrane Disassembly Nuclear Membrane Disassembly MAP Kinase Activity Muscle Cell Development Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Toxic Substance Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Outer Kinetochore Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Peptidyl-threonine Phosphorylation Microtubule Polymerization Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Regulation Of Circadian Rhythm Fc-epsilon Receptor Signaling Pathway Lymphocyte Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle G2/M Phase Transition Mononuclear Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Endoplasmic Reticulum Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Chromosome Segregation Regulation Of Chromosome Segregation Cellular Response To Hypoxia Response To Iron Ion Positive Regulation Of Cell Cycle G2/M Phase Transition Response To Light Stimulus