CLDN8 and ADAM32

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CLDN8	ADAM32
Name		claudin 8	ADAM metallopeptidase domain 32
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Anchoring Junction	Plasma Membrane Cell Surface Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity
	Biological Process	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly	Proteolysis Cell Adhesion Binding Of Sperm To Zona Pellucida Male Gonad Development
Pathways		Tight junction interactions	None
GWAS		Response to statin therapy ( 20339536 )	Herpes simplex virus 2 mgG-1 antibody levels ( 33204752 )
Interacting Genes		12 interacting genes: ADAM32 ARL13B CLEC17A ERGIC3 KASH5 OPRM1 PKMYT1 SMIM3 SYNE4 TJP1 TMEM80 TRARG1	1 interacting genes: CLDN8
Entrez ID		9073	203102
HPRD ID		10835	16475
Ensembl ID		ENSG00000156284	ENSG00000197140
Uniprot IDs		A0A0K0K1I9 P56748	A0A140VJD9 B4DTC2 Q8TC27
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Nuclear Outer Membrane	Cell-cell Adhesion Monocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Keratinocyte Migration Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Laminin Binding Cell Adhesion Response To Manganese Ion Amyloid Precursor Protein Metabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Macrophage Fusion Amyloid Precursor Protein Catabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Cell-cell Adhesion Mediated By Integrin Apicolateral Plasma Membrane Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Mediated By Integrin Membrane Protein Proteolysis Positive Regulation Of Epithelial Cell Migration Protein Kinase C Binding Regulation Of Cell Adhesion Mediated By Integrin Bicellular Tight Junction Assembly Tight Junction Assembly Tight Junction Organization Collagen Binding Keratinocyte Differentiation Regulation Of Epithelial Cell Migration