PHLDB2 and FLNC

Number of citations: 0 (PubMedID 12376540)
Data Source: HPRD (in vitro, in vivo)

		PHLDB2	FLNC
Name		pleckstrin homology like domain family B member 2	filamin C
Structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Membrane Cell Leading Edge Cell Projection Intermediate Filament Cytoskeleton Basal Cortex Anchoring Junction	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Sarcoplasm Z Disc Sarcolemma Costamere Intercellular Bridge
	Molecular Function	Protein Binding Cadherin Binding	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Microtubule Cytoskeleton Organization Cell Migration Establishment Of Cell Polarity Establishment Of Protein Localization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Basement Membrane Organization Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells	Actin Cytoskeleton Organization Sarcomere Organization Muscle Cell Development
Pathways		None	Cell-extracellular matrix interactions
Diseases		None	Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Atrial fibrillation ( 29892015 30061737 ) Cognitive performance ( 20125193 ) Crohn's disease-related phenotypes ( 25557950 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) PR interval ( 30046033 32439900 )	Dilated cardiomyopathy ( 33495596 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597 ) Reading disability or specific language impairment (pleiotropy) ( 25065397 ) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397 )
Interacting Genes		5 interacting genes: CLK1 FLNC USP7 YWHAG YWHAQ	35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		90102	2318
HPRD ID		06611	00018
Ensembl ID		ENSG00000144824	ENSG00000128591
Uniprot IDs		Q86SQ0	Q14315 Q59H94
PDB IDs		8WHJ 8WHK 8WHM	1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX 7OUU 7OUV 7P0E 8PA0
GO Terms Enriched among Interactors		Focal Adhesion Negative Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Regulation Of TOR Signaling Protein Kinase C Inhibitor Activity Symbiont-mediated Disruption Of Host Cell PML Body Protein Targeting Protein Domain Specific Binding Protein Stabilization Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi Cellular Response To Nutrient Levels Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Monoubiquitinated Protein Deubiquitination	Z Disc Alpha1-adrenergic Receptor Activity Actin Binding Neuron-glial Cell Signaling Actin Filament-based Process FATZ Binding Heart Contraction Telethonin Binding Actin Cytoskeleton Organization Heart Process Adrenergic Receptor Activity Sarcomere Organization Cytoplasm Circulatory System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-actinin Binding Striated Muscle Tissue Development Muscle Structure Development Adrenergic Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Regulation Of System Process Muscle Tissue Development Anchoring Junction M Band Cytoskeleton Organization Dystroglycan Complex Supramolecular Fiber Organization Muscle Contraction Sarcoglycan Complex Actomyosin Structure Organization Regulation Of Intracellular Signal Transduction Structural Constituent Of Muscle System Process Regulation Of Signal Transduction Regulation Of Skeletal Muscle Tissue Regeneration Muscle Organ Development Regulation Of Supramolecular Fiber Organization Regulation Of Muscle System Process Muscle System Process Regulation Of Actin Filament Organization Regulation Of Protein Processing Actin Cytoskeleton Regulation Of Protein Maturation Cardiac Muscle Tissue Development Titin Binding Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cytoskeleton Regulation Of Cell Communication