NAV2 and ING5

Number of citations: 0 (PubMedID 16189514)
Data Source: HPRD (two hybrid)

		NAV2	ING5
Name		neuron navigator 2	inhibitor of growth family member 5
Structure
GO Annotations	Cellular Component	Interstitial Matrix Nucleus Nucleoplasm Extracellular Matrix	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	Nucleotide Binding Helicase Activity Protein Binding ATP Binding Heparin Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K4me3 Reader Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Nervous System Development Sensory Perception Of Sound Sensory Perception Of Smell Locomotory Behavior Optic Nerve Development Glossopharyngeal Nerve Development Vagus Nerve Development Cerebellar Cortex Development Neurogenesis	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Organization Regulation Of DNA-templated Transcription Protein Acetylation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Growth Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Developmental Process Regulation Of Cell Cycle Apoptotic Signaling Pathway DNA Replication-dependent Chromatin Disassembly Regulation Of Hemopoiesis Regulation Of DNA Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		None	HATs acetylate histones Regulation of TP53 Activity through Acetylation
GWAS		Adverse response to drug ( 30420678 ) Atrial fibrillation ( 29892015 30061737 ) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery aneurysm in Kawasaki disease ( 27171184 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) General cognitive ability ( 29844566 ) Hepatitis ( 25705159 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Lateral thalamic nuclei volume ( 34006833 ) Low susceptibility to hepatitis C infection ( 31206233 ) Macular thickness ( 30535121 ) Monobrow ( 27182965 ) Obesity-related traits ( 23251661 ) PR interval ( 32439900 30046033 ) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762 ) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306 ) Waist circumference ( 28552196 )	Asthma ( 31959851 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Platelet distribution width ( 32888494 )
Interacting Genes		12 interacting genes: ADAT2 APC CFAP58 ING4 ING5 MORF4L1 PIAS2 PRPF3 PSTPIP1 RBM15 RBM15B RRAS	45 interacting genes: APC APLP1 ARFIP2 BARD1 BEX3 C3orf62 CBY2 CCDC33 CCHCR1 CDCA7L CDK2 CDKN1A CEP126 CEP44 DEUP1 EP300 FAM118B GCSH GGA1 GRIPAP1 HAP1 HGS HTT ICA1 IKZF3 KRT40 KRTAP10-7 KXD1 MBIP MCM6 MEST NAV2 ODF2 PCM1 PRMT5 RCOR3 SMARCE1 SUOX TADA3 TAF1D THAP6 TP53 TRIML2 VIM WASF1
Entrez ID		89797	84289
HPRD ID		07385	16348
Ensembl ID		ENSG00000166833	ENSG00000168395
Uniprot IDs		A7E2D6 Q8IVL1	A0A1B0GW41 Q8WYH8
PDB IDs		2YRN	3C6W 5ME8 5MTO
GO Terms Enriched among Interactors		DNA Replication-dependent Chromatin Disassembly Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Histone H3K4me3 Reader Activity Histone Acetyltransferase Complex Chromatin Organization RNA Modification Nucleoplasm Protein Acetylation Fibroblast Proliferation TRNA Wobble Adenosine To Inosine Editing TRNA-specific Adenosine-34 Deaminase Activity Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process RNA Methylation Regulation Of DNA Biosynthetic Process RNA Metabolic Process	Identical Protein Binding Centriole Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Protein Binding Cytosol Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Domain Specific Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Centriole Replication P53 Binding Membrane Curvature Sensor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Organization Centriole Assembly Organelle Transport Along Microtubule Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Transport Along Microtubule Regulation Of Cell Cycle G1/S Phase Transition Stress-induced Premature Senescence Protein-containing Complex Cytoskeleton-dependent Intracellular Transport Intracellular Transport Regulation Of Organelle Organization Microtubule-based Process Negative Regulation Of Mitotic Cell Cycle Nuclear Receptor Binding Neurogenesis Regulation Of Mitotic Cell Cycle Phase Transition Centrosome Regulation Of DNA Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Replication Microtubule-based Transport Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Negative Regulation Of Cyclin-dependent Protein Kinase Activity Nucleoplasm Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Centriole-centriole Cohesion Regulation Of Intracellular Protein Transport ATAC Complex Cellular Senescence Regulation Of Intracellular Transport Small GTPase-mediated Signal Transduction Establishment Of Organelle Localization Replicative Senescence