H2BC11 and LOX

Number of citations: 0 (PubMedID 12686141)
Data Source: HPRD (in vitro)

		H2BC11	LOX
Name		H2B clustered histone 11	lysyl oxidase
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Plasma Membrane CENP-A Containing Nucleosome	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix
	Molecular Function	Lipopolysaccharide Binding DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding Collagen Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Small Molecule Binding Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Antibacterial Humoral Response Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Localization To CENP-A Containing Chromatin Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Blood Vessel Development Osteoblast Differentiation Heart Development Response To Xenobiotic Stimulus Response To Hormone Regulation Of Gene Expression Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-lysine Oxidation Collagen Fibril Organization Bone Mineralization Lung Development Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Development Ascending Aorta Development Descending Aorta Development Protein Modification Process Regulation Of Apoptotic Process Regulation Of Megakaryocyte Differentiation Muscle Cell Cellular Homeostasis Elastic Fiber Assembly Blood Vessel Morphogenesis Response To Steroid Hormone Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Muscle Cell Development Cell Chemotaxis Connective Tissue Development DNA Biosynthetic Process Regulation Of Bone Development Cellular Response To Chemokine Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Elastic fibre formation Crosslinking of collagen fibrils
GWAS		No GWAS studies recorded	Central corneal thickness ( 32528159 ) Coronary artery disease ( 28714974 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Lung function (FEV1/FVC) ( 30804560 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Waist circumference adjusted for body mass index ( 34021172 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		4 interacting genes: JMJD6 LOX SPANXN2 TLX3	8 interacting genes: DHDDS DPT ELN H1-1 H1-5 H2BC11 H2BC21 MRE11
Entrez ID		8970	4015
HPRD ID		13657	01087
Ensembl ID		ENSG00000124635	ENSG00000113083
Uniprot IDs		P06899	B0AZT2 B7ZAJ4 D0PNI2 P28300
PDB IDs		2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WA9 3WAA 3WTP 4CAY 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B33 5B40 5CPI 5CPJ 5CPK 5FUG 5GSE 5GTC 5GXQ 5JRG 5VEY 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5Z30 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IPU 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JOU 6JR0 6JR1 6JXD 6K1I 6K1J 6K1K 6KVD 6KXV 6L49 6L4A 6L9Z 6LA2 6LA8 6LA9 6LAB 6LER 6M3V 6M44 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T90 6T93 6USJ 6V2K 6YOV 7BY0 7C0M 7CCQ 7CCR 7COW 7D1Z 7D20 7E8D 7K5X 7K5Y 7K60 7K61 7K63 7LYA 7LYB 7LYC 7NL0 7SCY 7SCZ 7VCL 7VZ4 7W9V 7WBV 7WBW 7WBX 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y7I 7YRD 7ZI4 8G57 8GUI 8GUJ 8GUK 8H0V 8H0W 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8I17 8IHL 8JH2 8JH3 8JH4 8JL9 8JLA 8JLB 8JLD 8JND 8JNE 8JNF 8KB5 8KCY 8KD1 8KE0 8OSJ 8OSK 8OSL 8OTS 8OTT 8QKT 8RBX 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8U14 8UPF 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8XBT 8XBU 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YNY 8YTI 9GMK 9GMR 9J0N 9J0O 9J0P 9J8M 9J8N 9J8O	Not available
GO Terms Enriched among Interactors		Descending Aorta Development Lung Development Ascending Aorta Development Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Blood Vessel Development Peptidyl-lysine Oxidation Negative Regulation Of Protein Homooligomerization Oxidative RNA Demethylase Activity Protein Demethylase Activity P-TEFb Complex Binding Negative Regulation Of Protein Oligomerization Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Heart Development Protein Oxidation Recognition Of Apoptotic Cell Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Oxidative Demethylation Peptidyl-lysine Hydroxylation Animal Organ Development Regulation Of Bone Development Elastic Fiber Assembly Demethylation Transcription Regulator Activator Activity Regulation Of Respiratory Gaseous Exchange By Nervous System Process GABAergic Neuron Differentiation Phagocytosis, Recognition Cellular Response To Chemokine Protein Hydroxylation Regulation Of Respiratory System Process Histone Demethylase Activity Oxidoreductase Activity Small Molecule Binding Apoptotic Cell Clearance Regulation Of Respiratory Gaseous Exchange Muscle Cell Cellular Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Extracellular Matrix Assembly Respiratory Gaseous Exchange By Respiratory System Neuron Fate Specification Erythrocyte Development Aorta Development Platelet-derived Growth Factor Receptor Signaling Pathway Sprouting Angiogenesis Regulation Of Megakaryocyte Differentiation	Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Chromatin Remodeling Chromosome Protein-DNA Complex Assembly Chromatin Organization Innate Immune Response In Mucosa Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Phosphatidylinositol Phosphate Binding Mucosal Immune Response Organ Or Tissue Specific Immune Response Chromosome Condensation Nucleosomal DNA Binding Regulation Of DNA Metabolic Process Negative Regulation Of DNA Recombination Mitochondrial Double-strand Break Repair Via Homologous Recombination Nicotinamide Phosphoribosyltransferase Activity Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Euchromatin Antibacterial Humoral Response Myosin II Heavy Chain Binding Histone H2AXY142 Phosphatase Activity Chromatin DNA Binding