AP1M1 and PIGR

Number of citations: 0 (PubMedID 10809756)
Data Source: HPRD (in vivo)

		AP1M1	PIGR
Name		adaptor related protein complex 1 subunit mu 1	polymeric immunoglobulin receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Azurophil Granule Membrane Receptor Complex Extracellular Exosome Secretory IgA Immunoglobulin Complex Bounding Membrane Of Organelle
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Polymeric Immunoglobulin Binding Polymeric Immunoglobulin Receptor Activity Transmembrane Signaling Receptor Activity
	Biological Process	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Receptor Clustering
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation	Neutrophil degranulation
GWAS		Coronary artery disease ( 33020668 )	Blood protein levels ( 30072576 ) Coronary atherosclerosis (increased number of diseased vessels) (traffic exposure interaction) ( 28355232 ) Inflammatory bowel disease ( 23128233 ) Metabolite levels ( 23823483 ) Precuneus cortex volume ( 31530798 )
Interacting Genes		103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16	4 interacting genes: AP1M1 CCL5 CD79A RAB3B
Entrez ID		8907	5284
HPRD ID		04639	01436
Ensembl ID		ENSG00000072958	ENSG00000162896
Uniprot IDs		B3KNH5 Q59EK3 Q9BXS5	P01833
PDB IDs		Not available	1XED 2OCW 3CHN 3CM9 5D4K 6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA 7K0C 7YSG 8SKU 8SKV
GO Terms Enriched among Interactors		Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process	Chemokine Receptor Antagonist Activity Chemokine (C-C Motif) Ligand 5 Signaling Pathway CCR4 Chemokine Receptor Binding IgM B Cell Receptor Complex Immune System Process B Cell Receptor Complex Myosin V Binding Regulation Of Dopamine Uptake Involved In Synaptic Transmission GTP-dependent Protein Binding Secretion By Cell Positive Regulation Of Neurotransmitter Uptake Regulation Of Vesicle Size Vesicle-mediated Transport Dopaminergic Synapse Secretion Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Neurotransmitter Uptake Exocytosis Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Receptor Signaling Protein Tyrosine Kinase Activator Activity Regulation Of Cell-cell Adhesion Mediated By Integrin Eosinophil Migration Positive Regulation Of Natural Killer Cell Chemotaxis Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Macrophage Apoptotic Process Macrophage Chemotaxis Eosinophil Chemotaxis Positive Regulation Of Neuroinflammatory Response Dendritic Cell Migration Phospholipase Activator Activity Dendritic Cell Chemotaxis Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Myeloid Cell Apoptotic Process Host-mediated Suppression Of Viral Transcription Positive Regulation Of Homotypic Cell-cell Adhesion Macrophage Migration Monocyte Chemotaxis Negative Regulation Of Chemokine-mediated Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Lymphocyte Chemotaxis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway CCR1 Chemokine Receptor Binding Positive Regulation Of T Cell Apoptotic Process Host-mediated Suppression Of Viral Proces