AP1G2 and CENPK

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		AP1G2	CENPK
Name		adaptor related protein complex 1 subunit gamma 2	centromere protein K
Structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Golgi-associated Vesicle Endosome Membrane Membrane Membrane Coat AP-1 Adaptor Complex Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Synapse Intracellular Vesicle	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Protein Transport Vesicle-mediated Transport	Mitotic Sister Chromatid Segregation Chromosome Segregation Kinetochore Assembly
Pathways		Lysosome Vesicle Biogenesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		Blood protein levels ( 30072576 ) Sudden cardiac arrest ( 21658281 )	Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Diverticular disease ( 30177863 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		13 interacting genes: AFTPH AP1S1 AP1S2 ATXN1L CENPK DANCR KDM1A NEDD4 PRMT6 RABEP1 SNCA SYNRG XRN1	10 interacting genes: AP1G2 HSPB1 MRFAP1L1 PCBD2 PEX14 RTN4IP1 SOX6 TRIM55 TRIM63 WASHC3
Entrez ID		8906	64105
HPRD ID		04638	13323
Ensembl ID		ENSG00000213983	ENSG00000123219
Uniprot IDs		O75843 Q86U03 Q86V28	D6RHD3 D6RJF0 Q9BS16
PDB IDs		2E9G 2YMT 3ZHF 4BCX	7PB4 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
GO Terms Enriched among Interactors		AP-1 Adaptor Complex Endocytosis Clathrin Adaptor Activity Trans-Golgi Network Membrane Protein Transport Import Into Cell Melanosome Assembly Vesicle-mediated Transport Platelet Dense Granule Organization Establishment Of Protein Localization Membrane Coat Cytoplasmic Vesicle Receptor-mediated Endocytosis Cytoplasmic Vesicle Membrane Cellular Localization Terminal Bouton Melanosome Organization Establishment Of Localization In Cell Intracellular Protein Transport Pigment Granule Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Negative Regulation Of Transcription By RNA Polymerase II Formation Of Structure Involved In A Symbiotic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Stem Cell Proliferation Cellular Response To Puromycin Cellular Response To Cycloheximide Histone H2AR3 Methyltransferase Activity Intracellular Protein Localization Secretory Granule Organization Intracellular Transport Clathrin-coated Pit Receptor Internalization Channel Inhibitor Activity Perinuclear Region Of Cytoplasm Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Clathrin-coated Vesicle Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Early Endosome Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Contractile Muscle Fiber