SQSTM1 and KEAP1

Number of citations: 76 (PubMedID 39098523)
Data Source: BioGRID (unspecified method, affinity chromatography technology, proximity labelling technology, affinity chromatography technology)

		SQSTM1	KEAP1
Name		sequestosome 1	kelch like ECH associated protein 1
Structure
GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Endosome Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Cytoplasmic Vesicle Intracellular Membraneless Organelle Amphisome Autolysosome Synapse Extracellular Exosome Sperm Midpiece Lewy Body Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Protein-containing Complex Centriolar Satellite
	Molecular Function	Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Protein Sequestering Activity Molecular Sequestering Activity Molecular Condensate Scaffold Activity	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Disordered Domain Specific Binding Transcription Regulator Inhibitor Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Pexophagy Temperature Homeostasis Immune System Process Response To Ischemia Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus Autophagy Apoptotic Process Endosome Organization Intracellular Protein Localization Positive Regulation Of Autophagy Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Brown Fat Cell Proliferation Protein K63-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Energy Homeostasis Response To Mitochondrial Depolarisation Negative Regulation Of Ferroptosis Membraneless Organelle Assembly Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Epidermal Cell Differentiation Protein K48-linked Ubiquitination Cellular Response To Interleukin-4 Negative Regulation Of Response To Oxidative Stress
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Neddylation Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2	Ub-specific processing proteases Neddylation Potential therapeutics for SARS KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation
Drugs		None	Dimethyl fumarate
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)	None
GWAS		Alzheimer's disease (late onset) ( 24162737 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 )	Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483 ) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483 ) Body mass index and waist-hip ratio (pleiotropy) ( 29868124 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 )
Interacting Genes		108 interacting genes: ACAD10 AIM2 ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNF CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 KPNA4 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MOAP1 MTDH NBR1 NCOR1 NEDD4 NEDD8 NLRP6 NR2F2 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PELI1 PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RNF26 RPL37 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIM27 TRIM55 TRIM63 TTN UBA52 UBB ULK2 USP8 VANGL2 VAPB WBP4 WDR81 WEE2-AS1 WWP2 YWHAZ	93 interacting genes: AK4 AMER1 ANKS1A ASTN1 ATF5 ATG5 BAD BPTF BTRC C2orf68 C6orf132 CARD10 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DDRGK1 EAF1 EGFR ERICH5 ETF1 FAM117B FBXL17 FXR1 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL24 KPNA6 LAMC1 LAMTOR5 LINC00239 LSM3 MAD2L1 MAPKBP1 MCC MCMBP MLST8 MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PAK1 PAQR4 PDCD6IP PLEC PRKAG1 PTMA PTTG1 RAF1 RB1 RBX1 RECK RELA RNF26 SGCE SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRERF1 TRIM15 TRIM59 UBC UBE2D1 USP15 WDR83 WHRN ZNF121 ZSCAN32
Entrez ID		8878	9817
HPRD ID		03319	12079
Ensembl ID		ENSG00000161011	ENSG00000079999
Uniprot IDs		Q13501	Q14145
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3 7R1O	1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A 7EXI 7K28 7K29 7K2A 7K2B 7K2C 7K2D 7K2E 7K2F 7K2G 7K2H 7K2I 7K2J 7K2K 7K2L 7K2M 7K2N 7K2O 7K2P 7K2Q 7K2R 7K2S 7Q5H 7Q6Q 7Q6S 7Q8R 7Q96 7X4W 7X4X 7XM2 7XM3 7XM4 7XM5 7XOT 8EHV 8EJR 8EJS 8IVG 8IVR 8IXS 8PKS 8PKU 8PKV 8PKW 8PKX 8WFG 8X34 8XGK 8XGV 9DU7 9ETX 9ETY
GO Terms Enriched among Interactors		Intracellular Signal Transduction Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Signal Transduction Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Cellular Response To Stress Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Growth Factor Transferase Activity Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Protein Kinase Activity Protein-containing Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Protein Metabolic Process Kinase Activity Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Identical Protein Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Catabolic Process Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Modification Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Negative Regulation Of Catabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Catabolic Process Response To Oxygen Levels Positive Regulation Of Biosynthetic Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Nucleus Positive Regulation Of Autophagy Import Into Nucleus Negative Regulation Of Apoptotic Signaling Pathway Response To Hypoxia Programmed Cell Death Regulation Of Type I Interferon Production