SQSTM1 and NTRK3

Number of citations: 0 (PubMedID 12471037)
Data Source: HPRD (in vivo)

		SQSTM1	NTRK3
Name		sequestosome 1	neurotrophic receptor tyrosine kinase 3
Structure
GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Endosome Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Cytoplasmic Vesicle Intracellular Membraneless Organelle Amphisome Autolysosome Synapse Extracellular Exosome Sperm Midpiece Lewy Body Glutamatergic Synapse	Cytoplasm Plasma Membrane Membrane Axon Receptor Complex Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Signaling Receptor Activity SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-modified Protein Reader Activity Protein Sequestering Activity Molecular Sequestering Activity Molecular Condensate Scaffold Activity	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Neurotrophin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Pexophagy Temperature Homeostasis Immune System Process Response To Ischemia Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus Autophagy Apoptotic Process Endosome Organization Intracellular Protein Localization Positive Regulation Of Autophagy Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Brown Fat Cell Proliferation Protein K63-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Energy Homeostasis Response To Mitochondrial Depolarisation Negative Regulation Of Ferroptosis Membraneless Organelle Assembly Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	Neuron Migration Cell Communication Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Heart Development Circadian Rhythm Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Myelination In Peripheral Nervous System Cell Differentiation Positive Regulation Of Cell Migration Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Response To Ethanol Ephrin Receptor Signaling Pathway Animal Organ Development Neuron Fate Specification Axon Extension Involved In Regeneration Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation System Development Positive Regulation Of Positive Chemotaxis Response To Corticosterone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Postsynaptic Density Assembly Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Regulation Of Neural Precursor Cell Proliferation
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Neddylation Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Receptor-type tyrosine-protein phosphatases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor
Drugs		None	Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)	Neuroblastoma
GWAS		Alzheimer's disease (late onset) ( 24162737 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 )	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Blood protein levels ( 30072576 ) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053 ) Gaucher disease severity ( 22388998 ) General risk tolerance (MTAG) ( 30643258 )
Interacting Genes		108 interacting genes: ACAD10 AIM2 ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNF CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 KPNA4 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MOAP1 MTDH NBR1 NCOR1 NEDD4 NEDD8 NLRP6 NR2F2 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PELI1 PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RNF26 RPL37 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIM27 TRIM55 TRIM63 TTN UBA52 UBB ULK2 USP8 VANGL2 VAPB WBP4 WDR81 WEE2-AS1 WWP2 YWHAZ	28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13
Entrez ID		8878	4916
HPRD ID		03319	01870
Ensembl ID		ENSG00000161011	ENSG00000140538
Uniprot IDs		Q13501	B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3 7R1O	1WWC 3V5Q 4YMJ 6KZC 6KZD
GO Terms Enriched among Interactors		Intracellular Signal Transduction Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Cytoplasm Signal Transduction Positive Regulation Of Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Cellular Response To Stress Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Growth Factor Transferase Activity Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Protein Kinase Activity Protein-containing Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen-containing Compound Regulation Of Protein Metabolic Process Kinase Activity Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Neurotrophin TRKA Receptor Binding ERBB Signaling Pathway Intracellular Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Nerve Growth Factor Signaling Pathway Response To Epidermal Growth Factor Glial Cell Development Schwann Cell Development Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Intracellular Signaling Cassette Insulin Receptor Binding Positive Regulation Of Defense Response ERBB2 Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Apoptotic Process Interleukin-34-mediated Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Programmed Cell Death Interleukin-1-mediated Signaling Pathway Early Endosome Positive Regulation Of ERK1 And ERK2 Cascade Ephrin Receptor Binding Neurotrophin Signaling Pathway Cell Population Proliferation Cytosol Regulation Of Golgi Inheritance