CCK and CCKBR

Number of citations: 0 (PubMedID 15068617)
Data Source: HPRD (in vivo, in vitro)

		CCK	CCKBR
Name		cholecystokinin	cholecystokinin B receptor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon	Plasma Membrane Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Peptide Hormone Receptor Binding	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Protein Binding Neuropeptide Receptor Activity Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Neuron Migration Signal Transduction Axonogenesis Digestion Cholecystokinin Signaling Pathway Eating Behavior	Gastric Acid Secretion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Positive Regulation Of Cell Population Proliferation Cholecystokinin Signaling Pathway PH Reduction Digestive Tract Development Gland Development
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Camostat	Pentagastrin Cholecystokinin
GWAS		Adult body size ( 32376654 ) Body mass index ( 24348519 28448500 28892062 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (SNP x SNP interaction) ( 22344221 ) Body size at age 10 ( 32376654 ) Night sleep phenotypes ( 27126917 )	Diastolic blood pressure ( 30224653 ) Early spontaneous preterm birth ( 31194736 ) Gastroesophageal reflux disease ( 31527586 ) Malaria ( 31844061 ) Rheumatic heart disease ( 34106200 )
Interacting Genes		7 interacting genes: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2	10 interacting genes: ADRB2 ATP13A2 CCK CCKAR CCR4 DRD2 NTM PPP1R9B PTPN11 SLCO1B3
Entrez ID		885	887
HPRD ID		00321	00323
Ensembl ID		ENSG00000187094	ENSG00000110148
Uniprot IDs		P06307 Q6FG82	E9PIC8 P32239
PDB IDs		7EZH 7EZK 7EZM 7MBX 7MBY 7XOU 8IA7 9BKJ 9BKK	1L4T 7F8V 7F8W 7XOW 8IA7
GO Terms Enriched among Interactors		Cholecystokinin Receptor Activity Metallopeptidase Activity Meprin A Complex Cholecystokinin Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Regulation Of Hormone Levels Proteolysis Protein Processing Hormone Metabolic Process Plasma Membrane Peptide Hormone Binding Protein Maturation Peptide Metabolic Process Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Glutamyl Aminopeptidase Activity Metalloendopeptidase Activity Neuropeptide Signaling Pathway Epidermal Growth Factor Receptor Ligand Maturation Negative Regulation Of G Protein-coupled Receptor Internalization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Localization To Secretory Granule Regulation Of Biological Quality Membrane Extracellular Space Negative Regulation Of Clathrin-dependent Endocytosis Hydrolase Activity Protein Metabolic Process 1-phosphatidylinositol-3-kinase Regulator Activity G Protein-coupled Receptor Signaling Pathway PH Reduction Gastric Acid Secretion Metallodipeptidase Activity Insulin Processing Cytoplasmic Vesicle Zinc Ion Binding Cardiac Left Ventricle Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Neurexin Family Protein Binding Glomerulus Development Negative Regulation Of Receptor Internalization Insulin Metabolic Process Peptide Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Neuropeptide Receptor Activity G Protein-coupled Receptor Activity	Cholecystokinin Signaling Pathway Axonogenesis Neuron Migration Cell Migration Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Motility Peptide Hormone Receptor Binding Regulation Of Growth Hormone Secretion Interneuron Migration G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Response To Morphine Regulation Of G Protein-coupled Receptor Signaling Pathway Multicellular Organismal-level Homeostasis Response To Amphetamine Temperature Homeostasis Cell Projection Organization Regulation Of Secretion By Cell Potassium Channel Regulator Activity Negative Regulation Of Blood Pressure Regulation Of Secretion Response To Nicotine Response To Amine Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Cellular Response To Epidermal Growth Factor Stimulus Smooth Muscle Contraction Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Ossification Homeostatic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Hormone Secretion Positive Regulation Of Secretion By Cell Regulation Of Protein Secretion Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Response To Epidermal Growth Factor Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Regulation Of Multicellular Organism Growth Positive Regulation Of Secretion Negative Regulation Of Hormone Secretion Regulation Of Sodium Ion Transport Forebrain Development