CCK and CCKAR

Number of citations: 31 (PubMedID 10595537)
Data Source: HPRD (in vitro, in vivo)

		CCK	CCKAR
Name		cholecystokinin	cholecystokinin A receptor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Axon	Nucleoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Peptide Hormone Receptor Binding	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Peptide Hormone Binding
	Biological Process	Neuron Migration Signal Transduction Axonogenesis Digestion Cholecystokinin Signaling Pathway Eating Behavior	Neuron Migration Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Forebrain Development Cellular Response To Hormone Stimulus Cholecystokinin Signaling Pathway Regulation Of Hormone Secretion
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Camostat	Ceruletide Dexloxiglumide Lintitript Cholecystokinin
GWAS		Adult body size ( 32376654 ) Body mass index ( 24348519 28448500 28892062 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (SNP x SNP interaction) ( 22344221 ) Body size at age 10 ( 32376654 ) Night sleep phenotypes ( 27126917 )	No GWAS studies recorded
Interacting Genes		7 interacting genes: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2	3 interacting genes: CCK CCKBR PPP1R9B
Entrez ID		885	886
HPRD ID		00321	00322
Ensembl ID		ENSG00000187094	ENSG00000163394
Uniprot IDs		P06307 Q6FG82	P32238
PDB IDs		7EZH 7EZK 7EZM 7MBX 7MBY 7XOU 8IA7 9BKJ 9BKK	1D6G 1HZN 7EZH 7EZK 7EZM 7F8U 7F8X 7F8Y 7MBX 7MBY 7XOU 7XOV 9BKJ 9BKK
GO Terms Enriched among Interactors		Cholecystokinin Receptor Activity Metallopeptidase Activity Meprin A Complex Cholecystokinin Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Regulation Of Hormone Levels Proteolysis Protein Processing Hormone Metabolic Process Plasma Membrane Peptide Hormone Binding Protein Maturation Peptide Metabolic Process Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Glutamyl Aminopeptidase Activity Metalloendopeptidase Activity Neuropeptide Signaling Pathway Epidermal Growth Factor Receptor Ligand Maturation Negative Regulation Of G Protein-coupled Receptor Internalization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Localization To Secretory Granule Regulation Of Biological Quality Membrane Extracellular Space Negative Regulation Of Clathrin-dependent Endocytosis Hydrolase Activity Protein Metabolic Process 1-phosphatidylinositol-3-kinase Regulator Activity G Protein-coupled Receptor Signaling Pathway PH Reduction Gastric Acid Secretion Metallodipeptidase Activity Insulin Processing Cytoplasmic Vesicle Zinc Ion Binding Cardiac Left Ventricle Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Neurexin Family Protein Binding Glomerulus Development Negative Regulation Of Receptor Internalization Insulin Metabolic Process Peptide Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Neuropeptide Receptor Activity G Protein-coupled Receptor Activity	Cholecystokinin Signaling Pathway Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Cholecystokinin Receptor Activity MAML1-RBP-Jkappa- ICN1 Complex Endocardium Morphogenesis Blood Vessel Endothelial Cell Fate Specification Blood Vessel Lumenization Auditory Receptor Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis D2 Dopamine Receptor Binding Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Opioid Receptor Signaling Pathway Cellular Response To Morphine Club Cell Differentiation Epidermal Cell Fate Specification Pulmonary Valve Development Endothelial Cell Fate Specification Response To Kainic Acid Spine Apparatus 1-phosphatidylinositol-3-kinase Regulator Activity Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Aortic Valve Development Hair Follicle Maturation Endocardium Development Semi-lunar Valve Development Protein Localization To Actin Cytoskeleton Dendritic Spine Head Positive Regulation Of Protein Localization To Cell Cortex Response To L-phenylalanine Derivative Gland Development PH Reduction Positive Regulation Of Transcription Of Notch Receptor Target Male Mating Behavior Gastric Acid Secretion Sebaceous Gland Development Dorsal Aorta Morphogenesis Extrinsic Component Of Postsynaptic Membrane Cellular Response To Peptide Regulation Of Protein Localization To Cell Cortex Atrioventricular Canal Development Peptide Hormone Receptor Binding Cardiac Muscle Cell Myoblast Differentiation Secondary Heart Field Specification Cardiac Left Ventricle Morphogenesis