GMPS and AGPAT2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		GMPS	AGPAT2
Name		guanine monophosphate synthase	1-acylglycerol-3-phosphate O-acyltransferase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	Nucleotide Binding GMP Synthase Activity GMP Synthase (glutamine-hydrolyzing) Activity ATP Binding Ligase Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Acyltransferase Activity
	Biological Process	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process	Positive Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Epidermis Development Phospholipid Biosynthetic Process Response To Xenobiotic Stimulus CDP-diacylglycerol Biosynthetic Process Triglyceride Biosynthetic Process
Pathways		Purine ribonucleoside monophosphate biosynthesis Azathioprine ADME	Synthesis of PA Neutrophil degranulation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Glutamic acid	None
Diseases		None	Congenital generalized lipodystrophy (CGL)
GWAS		Blood metabolite levels ( 27453504 ) Cardiorespiratory fitness (800m run time) ( 32572135 )	No GWAS studies recorded
Interacting Genes		6 interacting genes: AGPAT2 CEBPA FILNC1 RNF26 SUMO4 USP7	6 interacting genes: ABCG8 ANKRD28 GMPS PHF11 PHRF1 SLC23A2
Entrez ID		8833	10555
HPRD ID		10927	04373
Ensembl ID		ENSG00000163655	ENSG00000169692
Uniprot IDs		A0A140VJK6 P49915	A0A024R8F9 O15120
PDB IDs		2VPI 2VXO	Not available
GO Terms Enriched among Interactors		None	GMP Synthase (glutamine-hydrolyzing) Activity GMP Synthase Activity L-ascorbic Acid Transmembrane Transport L-ascorbic Acid Transmembrane Transporter Activity L-ascorbate:sodium Symporter Activity Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Absorption ATP-binding Cassette (ABC) Transporter Complex Purine Nucleobase Biosynthetic Process L-ascorbic Acid Metabolic Process Protein Serine/threonine Phosphatase Complex Intestinal Cholesterol Absorption Regulation Of Intestinal Cholesterol Absorption Regulation Of Intestinal Lipid Absorption Intestinal Lipid Absorption Regulation Of Intestinal Absorption GMP Biosynthetic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Cellular Response To Ethanol Apical Plasma Membrane Positive Regulation Of Dendrite Extension Vitamin Transmembrane Transport RNA Polymerase Binding