HESX1 and PRMT6

Number of citations: 0 (PubMedID 23455924)
Data Source: BioGRID (affinity chromatography technology, two hybrid)

		HESX1	PRMT6
Name		HESX homeobox 1	protein arginine methyltransferase 6
Structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Gonad Development Gene Expression Wnt Signaling Pathway Stem Cell Population Maintenance Pituitary Gland Development Thyroid Gland Development Forebrain Development Otic Vesicle Formation Multicellular Organism Growth Camera-type Eye Development Nose Development Negative Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Canonical Wnt Signaling Pathway ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		None	RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Septo-optic dysplasia	None
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Family history of Alzheimer's disease ( 30617256 )	Adult body size ( 32376654 ) Blood pressure measurement (low sodium intervention) ( 24165912 ) Intelligence ( 22449649 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Non-obstructive azoospermia ( 22197933 ) Obesity (early onset extreme) ( 23563609 ) Refractive error ( 32231278 ) Response to SSRI in MDD or openness ( 29559929 ) Restless legs syndrome ( 29029846 ) Sex hormone-binding globulin levels ( 22829776 ) Waist circumference ( 28552196 ) Weight ( 28552196 )
Interacting Genes		12 interacting genes: AIRIM CATIP GUCD1 HOXC8 KDM1A NCOR1 NPAS2 PRMT6 PROP1 STAT3 TLE1 UBL5	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		8820	55170
HPRD ID		03482	10505
Ensembl ID		ENSG00000163666	ENSG00000198890
Uniprot IDs		Q9UBX0	Q96LA8
PDB IDs		2K40	4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4
GO Terms Enriched among Interactors		Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of Glycolytic Process Nucleus Negative Regulation Of ATP Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Glycolytic Process Histone H2AR3 Methyltransferase Activity Regulation Of Carbohydrate Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Behavior Hypophysis Morphogenesis Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Intracellular Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Response To CAMP Regulation Of MiRNA Metabolic Process Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Catabolic Process Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Somatotropin Secreting Cell Differentiation RNA Sequestering Activity Protein Demethylase Activity	Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus