TNFSF10 and TNFRSF11B

Number of citations: 35 (PubMedID 9520411)
Data Source: HPRD (in vitro)

		TNFSF10	TNFRSF11B
Name		TNF superfamily member 10	TNF receptor superfamily member 11b
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Receptor Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding TRAIL Binding Metal Ion Binding	Cytokine Activity Protein Binding Signaling Receptor Activity Heparan Sulfate Binding
	Biological Process	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Signaling TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Skeletal System Development Apoptotic Process Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Osteoclast Differentiation
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling	TNFs bind their physiological receptors
Diseases		None	Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Alanine aminotransferase levels ( 33547301 34315874 ) Aspartate aminotransferase levels ( 33547301 34315874 ) Breast cancer ( 28171663 ) Breast cancer (estrogen-receptor negative) ( 28171663 ) Carotid plaque burden ( 28282560 ) Cocaine dependence ( 31212010 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Liver volume ( 34128465 ) Monocyte percentage of white cells ( 27863252 ) TRAIL levels ( 27989323 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 )	Asthma ( 29273806 ) Asthma (childhood onset) ( 30929738 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Bone mineral density ( 18455228 23437003 24249740 ) Bone mineral density (hip) ( 19801982 27311723 ) Bone mineral density (paediatric, skull) ( 24945404 ) Bone mineral density (spine) ( 19801982 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of white cells ( 32888494 ) Femoral neck bone mineral density ( 29499414 ) Heel bone mineral density ( 30598549 28869591 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lumbar spine bone mineral density ( 29499414 22504420 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lumbar spine bone mineral density (trabecular) ( 27476799 ) Medication use (thyroid preparations) ( 31015401 ) Metabolite levels ( 23823483 ) Osteoporosis-related phenotypes ( 20548944 ) Osteoprotegerin levels ( 25080503 ) Physiological traits ( 31902109 ) Serum alkaline phosphatase levels ( 29403010 31666285 33547301 ) Serum sclerostin levels ( 31170332 ) Sum eosinophil basophil counts ( 27863252 ) Type 1 diabetes ( 21980299 )
Interacting Genes		10 interacting genes: ACP5 CASP3 CFTR RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17	7 interacting genes: FN1 THBS1 TNFSF10 TNFSF11 TNFSF13 VTN VWF
Entrez ID		8743	4982
HPRD ID		04670	04032
Ensembl ID		ENSG00000121858	ENSG00000164761
Uniprot IDs		P50591 Q6IBA9	O00300
PDB IDs		1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR	3URF
GO Terms Enriched among Interactors		TRAIL Binding TRAIL-activated Apoptotic Signaling Pathway Death Receptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Apoptotic Process Programmed Cell Death Activation Of NF-kappaB-inducing Kinase Activity Cell Surface Apoptotic Signaling Pathway Golgi-associated Vesicle Membrane Extrinsic Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Activation Of Protein Kinase Activity Signaling Receptor Activity Negative Regulation Of Superoxide Anion Generation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding TRAIL Receptor Activity Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Phospholipase A2 Activator Activity Positive Regulation Of Anion Channel Activity Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Protease Binding Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Monoatomic Anion Transport Multicellular Organismal-level Homeostasis Anterior Neural Tube Closure Cellular Response To Staurosporine Positive Regulation Of Enamel Mineralization Positive Regulation Of Protein Kinase Activity Luteolysis Glial Cell Apoptotic Process Transepithelial Water Transport Positive Regulation Of Kinase Activity Protein-cysteine S-myristoyltransferase Activity Negative Regulation Of Immune System Process Acid Phosphatase Activity Response To Anesthetic Positive Regulation Of Tooth Mineralization Protein-cysteine S-stearoyltransferase Activity Ferric Iron Binding Death-inducing Signaling Complex	Extracellular Space Extracellular Matrix Structural Constituent Integrin Binding Tumor Necrosis Factor Receptor Binding Extracellular Region Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Collagen Binding Platelet Alpha Granule Lumen Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Signal Transduction Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Cell Communication Signaling Receptor Binding Protease Binding Positive Regulation Of Signaling Negative Regulation Of Fibrinolysis Extracellular Matrix Proteoglycan Binding Extracellular Exosome Regulation Of Fibrinolysis Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Activation Cascade Heparin Binding Cell-substrate Adhesion Platelet Alpha Granule Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response Positive Regulation Of Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Activation Positive Regulation Of Coagulation Extracellular Matrix Binding Cytokine Activity Regulation Of Fatty Acid Transport Regulation Of Cell-substrate Adhesion Endodermal Cell Differentiation Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Cell Adhesion Identical Protein Binding Cell Migration Immune System Process Positive Regulation Of Wound Healing Regulation Of Blood Coagulation Regulation Of Cell Communication