CTNNAL1 and NEK1

Number of citations: 0 (PubMedID 14690447)
Data Source: HPRD (two hybrid)

		CTNNAL1	NEK1
Name		catenin alpha like 1	NIMA related kinase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Centriolar Satellite
	Molecular Function	Protein Binding Cadherin Binding Actin Filament Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Rho Protein Signal Transduction	Protein Phosphorylation Cell Projection Organization Cell Division Cilium Assembly
Pathways		None	Regulation of pyruvate metabolism
Drugs		None	Fostamatinib
Diseases		None	Short rib-polydactyly syndrome
GWAS		No GWAS studies recorded	Autism spectrum disorder or schizophrenia ( 28540026 ) Daytime nap ( 33568662 ) Night sleep phenotypes ( 27126917 ) Schizophrenia ( 25056061 28991256 29483656 ) Supramarginal gyrus volume ( 31530798 )
Interacting Genes		11 interacting genes: AKAP13 BRME1 CALU DMD NEK1 PCGF2 SERTAD3 TRIM7 TSC22D4 USH1C ZBED1	19 interacting genes: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD SIRPA TP53BP1 TSC2 YAP1 YWHAH ZNF350
Entrez ID		8727	4750
HPRD ID		09210	06847
Ensembl ID		ENSG00000119326	ENSG00000137601
Uniprot IDs		B3KMX6 Q9UBT7	A0A8I5KUL6 Q96PY6
PDB IDs		Not available	4APC 4B9D
GO Terms Enriched among Interactors		None	Negative Regulation Of Cellular Component Organization Negative Regulation Of Macroautophagy Negative Regulation Of Autophagosome Assembly Negative Regulation Of Autophagy Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Organelle Assembly Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Vacuole Organization Negative Regulation Of Cell Projection Organization Glutamatergic Synapse DNA Strand Resection Involved In Replication Fork Processing Regulation Of Macroautophagy Negative Regulation Of Catabolic Process Regulation Of Organelle Organization Cellular Response To Stress Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Projection Development Regulation Of Cell Projection Organization Positive Regulation Of Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization DNA Damage Response Response To Stress Negative Regulation Of Macromolecule Metabolic Process Protein Binding Negative Regulation Of Gene Expression Regulation Of Reactive Oxygen Species Metabolic Process Vesicle Membrane Transcription Factor TFIID Complex Replication Fork Regulation Of Cellular Response To Stress Mitochondrial Double-strand Break Repair Via Homologous Recombination Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Postsynapse Organization Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Endocytosis Glucocorticoid Catabolic Process Clathrin Binding Positive Regulation Of Membrane Permeability