URI1 and GTF2F2

Number of citations: 0 (PubMedID 12737519)
Data Source: HPRD (in vitro, in vivo)

		URI1	GTF2F2
Name		URI1 prefoldin like chaperone	general transcription factor IIF subunit 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Dendrite Protein-containing Complex Cell Projection Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Microtubule Cytoskeleton RNA Polymerase II, Holoenzyme RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Transcription Corepressor Activity Protein Phosphatase Inhibitor Activity Protein Binding Phosphatase Inhibitor Activity Phosphoprotein Binding	DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of Transcription By RNA Polymerase II Response To Virus Negative Regulation Of Phosphatase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Stabilization Cellular Response To Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		None	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
GWAS		Body mass index ( 26426971 ) Cerebrospinal P-tau181p levels ( 28247064 ) Diastolic blood pressure ( 27841878 ) Serum urate levels in chronic kidney disease ( 30181573 )	Normal facial asymmetry (angle of surface orientation score) ( 30631343 ) Type 2 diabetes ( 25760438 )
Interacting Genes		11 interacting genes: AKT1 APP ATF7 DMAP1 GTF2F2 ITCH NEDD4 POLR2E RPS6KB1 STAP1 TRIM28	30 interacting genes: AHR AR ARNT ATF2 ATF4 CEBPA CEBPG CREB1 DYNLT2B FHL2 FOS GTF2B GTF2E1 GTF2E2 GTF2F1 HMGA1 HTATSF1 JUN KLF5 MAPRE3 MSX2 POLR2E RPL27A TAF5 TBP TCEA1 TRAM2 URI1 YEATS4 ZMYND19
Entrez ID		8725	2963
HPRD ID		11943	01804
Ensembl ID		ENSG00000105176	ENSG00000188342
Uniprot IDs		O94763	P13984
PDB IDs		Not available	1BBY 1F3U 2BBY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWD 7ZX7 7ZX8 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S54 8S55 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 8WAT 8WAU 8WAV 8WAW 8WAX 8WAY 8WAZ 8WB0
GO Terms Enriched among Interactors		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Protein-containing Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Transport Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Protein K29-linked Ubiquitination Negative Regulation Of Cell Communication Regulation Of TORC2 Signaling Positive Regulation Of Protein Localization To Nucleus Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Regulation Of Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Intracellular Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Macromolecule Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Protein Metabolic Process Defense Response Post-translational Protein Modification Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Localization Nucleoplasm Positive Regulation Of Defense Response Cell Cortex Negative Regulation Of Macromolecule Biosynthetic Process Proteasomal Protein Catabolic Process Negative Regulation Of Mononuclear Cell Migration	DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIID Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Positive Regulation Of RNA Metabolic Process RNA Metabolic Process Transcription Regulator Complex Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding MRNA Transcription Promoter-specific Chromatin Binding DNA-templated Transcription Initiation Sequence-specific Double-stranded DNA Binding Integrated Stress Response Signaling Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Gene Expression RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Initiation