SNX4 and LEPR

Number of citations: 41 (PubMedID 9819414)
Data Source: HPRD (in vivo)

		SNX4	LEPR
Name		sorting nexin 4	leptin receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytoplasmic Dynein Complex Plasma Membrane Membrane SNARE Complex Early Endosome Membrane Protein-containing Complex Presynaptic Endosome	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity Signaling Receptor Activity Identical Protein Binding
	Biological Process	Protein Transport Endocytic Recycling Positive Regulation Of Histamine Secretion By Mast Cell Positive Regulation Of Autophagosome Assembly	Angiogenesis Glycogen Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Glial Cell Proliferation Cytokine-mediated Signaling Pathway Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling System Development Regulation Of Transport Regulation Of Feeding Behavior Energy Homeostasis Cell Surface Receptor Signaling Pathway Via STAT Bone Growth Positive Regulation Of Cold-induced Thermogenesis Transport Across Blood-brain Barrier
Drugs		None	Leptin Metreleptin
GWAS		Adult body size ( 32376654 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Major depressive disorder x sex interaction ( 34099189 ) Urate levels ( 31578528 )	Adult body size ( 32376654 ) Age at voice drop ( 27182965 ) Alanine aminotransferase levels ( 34315874 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Blood protein levels ( 30072576 ) BMI at 1 year old ( 31575865 ) BMI at 1.5 years old ( 31575865 ) BMI at 3 months old ( 31575865 ) BMI at 6 months old ( 31575865 ) BMI at 8 months old ( 31575865 ) BMI at adiposity peak ( 31840077 ) Body size at age 10 ( 32376654 ) C-reactive protein ( 23844046 18439548 22939635 19567438 ) C-reactive protein levels ( 33339817 21300955 29878111 30388399 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Eosinophil percentage of white cells ( 32888494 ) Fasting plasma glucose (childhood) ( 25223902 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Granulocyte count ( 27863252 ) HDL cholesterol levels ( 32203549 ) Hemoglobin ( 32888494 ) Hip circumference ( 28552196 ) Iron status biomarkers (iron levels) ( 33536631 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Menarche (age at onset) ( 25231870 ) Metabolic traits ( 19060910 ) Molybdenum levels ( 26025379 ) Monocyte percentage of white cells ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Nonalcoholic steatohepatitis ( 32298765 ) Obesity (early onset extreme) ( 23563609 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Soluble leptin receptor levels ( 20167575 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 27863252 )
Interacting Genes		18 interacting genes: AGK ARL6IP1 ATP6V0A1 BIN1 DGAT2L6 EGFR HIVEP1 INSR LEPR MAGEA6 OGT PDGFRA PDGFRB PTPN5 SH3GLB1 SNX2 SNX6 SUPT5H	17 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 USP7 XRN1
Entrez ID		8723	3953
HPRD ID		09334	03001
Ensembl ID		ENSG00000114520	ENSG00000116678
Uniprot IDs		O95219	P48357 Q4G138
PDB IDs		Not available	3V6O 6E2P 7Z3Q 8AVE 8AVF 8AVO 8X80 8X81 8X85
GO Terms Enriched among Interactors		Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Autophagy Receptor Complex Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Protein Tyrosine Kinase Activity Glomerular Capillary Formation Lipid Binding Regulation Of Macroautophagy Platelet-derived Growth Factor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet-derived Growth Factor Receptor Binding Retina Vasculature Development In Camera-type Eye Cardiac Myofibril Assembly Regulation Of Glucose Metabolic Process Cellular Response To Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Endosome Membrane Membrane Retromer Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphorus Metabolic Process Protein Autophosphorylation Response To Growth Factor Adrenal Gland Development Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Myofibril Assembly Negative Regulation Of ERBB Signaling Pathway Cellular Localization Negative Regulation Of Catabolic Process Phosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Process Endosome Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Organelle Organization Protein-containing Complex Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Leptin Receptor Activity Platelet-derived Growth Factor Alpha-receptor Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development	Leptin Receptor Binding Retromer, Tubulation Complex Insulin Receptor Binding Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Peptide Hormone Receptor Binding Transferrin Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Metabolic Process Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Autophagy Retromer Complex Negative Regulation Of Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Cytosol Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Autophagy Phosphatidylinositol Binding Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Regulation Of Hormone Secretion Regulation Of Intracellular Transport Epidermal Growth Factor Receptor Binding Regulation Of Nucleocytoplasmic Transport Regulation Of Transport Regulation Of Immune System Process Regulation Of Defense Response Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hormone Secretion Establishment Of Protein Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus