TNFRSF25 and TNFSF12

Number of citations: 0 (PubMedID 11094155)
Data Source: HPRD (in vivo)

		TNFRSF25	TNFSF12
Name		TNF receptor superfamily member 25	TNF superfamily member 12
Structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Tumor Necrosis Factor Receptor Activity Signaling Receptor Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Immune Response Signal Transduction Cell Differentiation Endothelial Cell Migration Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFs bind their physiological receptors	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
GWAS		No GWAS studies recorded	Alcohol consumption (drinks per week) ( 30643258 ) Apolipoprotein A1 levels ( 32203549 ) Atrial fibrillation ( 29892015 30061737 ) Brain morphology (MOSTest) ( 32665545 ) Chin dimples ( 27182965 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Emotional recognition ( 31596458 ) HDL cholesterol levels ( 32203549 ) Myopia ( 27182965 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Triglyceride levels ( 32203549 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		9 interacting genes: BAG4 DAP3 DYRK1A MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2	6 interacting genes: AGGF1 DDIT3 LMNA SGTA TNFRSF12A TNFRSF25
Entrez ID		8718	8742
HPRD ID		04532	04074
Ensembl ID		ENSG00000215788	ENSG00000239697
Uniprot IDs		Q93038	O43508 Q4ACW9
PDB IDs		5YGP 5YGS	4HT1
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Superfamily Complex Non-canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Tumor Necrosis Factor Negative Regulation Of MRNA Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Intracellular Signaling Cassette Regulation Of Apoptotic Process Receptor Complex Regulation Of Programmed Cell Death Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Histone H3T45 Kinase Activity Diuretic Hormone Activity Positive Regulation Of Protein Phosphorylation Response To Epidermal Growth Factor Fructose Import Across Plasma Membrane Positive Regulation Of Signal Transduction TORC2 Complex Disassembly Negative Regulation Of MRNA Modification Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Cytosine Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly	Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Determination Of Dorsal Identity Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress CHOP-ATF4 Complex CHOP-ATF3 Complex Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina TRC Complex Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Apoptotic Signaling Pathway Involuntary Skeletal Muscle Contraction CHOP-C/EBP Complex Diaphragm Contraction Cellular Response To Nitrosative Stress Identical Protein Binding Vascular Associated Smooth Muscle Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity BAT3 Complex Binding GDF15-GFRAL Signaling Pathway Lamin Filament Nuclear Pore Localization Cell Death ATF6-mediated Unfolded Protein Response HRI-mediated Signaling Apoptotic Process Response To Endoplasmic Reticulum Stress Blood Vessel Maturation Negative Regulation Of Interleukin-4 Production Response To Nitrosative Stress Programmed Cell Death Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of ERAD Pathway Transcription Regulator Activator Activity PERK-mediated Unfolded Protein Response ER Overload Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway CAMP Response Element Binding Protein Binding Response To Caloric Restriction Leucine Zipper Domain Binding Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress