STX11 and VAMP2

Number of citations: 0 (PubMedID 10036234)
Data Source: HPRD (in vitro)

		STX11	VAMP2
Name		syntaxin 11	vesicle associated membrane protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Endomembrane System Membrane SNARE Complex Presynaptic Active Zone Membrane	Trans-Golgi Network Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Transport Vesicle Clathrin-coated Vesicle Secretory Granule Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Vesicle Zymogen Granule Membrane Neuron Projection Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding
	Biological Process	Intracellular Protein Transport Exocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Membrane Fusion	Exocytosis Vesicle Fusion Response To Glucose Protein Transport Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Cellular Response To Insulin Stimulus SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Eosinophil Degranulation Neutrophil Degranulation Natural Killer Cell Degranulation Synaptic Vesicle Endocytosis Long-term Synaptic Potentiation Regulation Of Vesicle-mediated Transport Membrane Fusion Protein-containing Complex Assembly Mucus Secretion Positive Regulation Of Intracellular Protein Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Histamine Secretion By Mast Cell
Pathways		None	Translocation of SLC2A4 (GLUT4) to the plasma membrane Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle trans-Golgi Network Vesicle Budding Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Other interleukin signaling Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type B (botB) Toxicity of botulinum toxin type F (botF) Toxicity of tetanus toxin (tetX) Toxicity of botulinum toxin type G (botG) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
Drugs		None	Botulinum toxin type B
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency	None
GWAS		Nicotine dependence symptom count ( 25555482 ) Pre-treatment viral load in HIV-1 infection ( 31219150 )	Chronotype ( 30696823 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Morning person ( 30696823 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 )
Interacting Genes		98 interacting genes: AIRIM APP AXIN1 AXIN2 BLOC1S6 BYSL CARD9 CCBE1 CCDC120 CCDC125 CCDC184 CCDC196 CCDC33 CCHCR1 CCNK CDCA7L CDR2L CRYBA4 CTBP2 CWF19L2 DISC1 DUSP29 EIF1AD EIF2B5 FAM110A FAM161A FAM161B FAM74A4 FAM90A1 FARS2 GOLGA8EP GOLGA8F HAUS1 HGS HOXA1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KIFC3 KLC3 KRT75 KXD1 LENG1 LONRF1 MAGOHB MBD3L1 MBIP MEOX2 MFAP1 MID2 MIS18A MTCL2 NDC80 NTAQ1 PKN1 PPP1R18 PRKAB2 PRPF18 PRPF31 PSMA3 PSMC3 RAD51D RNF6 RNF8 RNPS1 RUNX1T1 SCNM1 SH2D4A SHC3 SIKE1 SLC38A2 SMARCE1 SNAP23 SNAP25 SNCA SNX3 STX1A STX4 SUV39H1 TADA3 TAF6L TBK1 TCEA2 TCF4 TLE5 TNFRSF21 TRIM41 TSGA10IP UBASH3A USHBP1 VAMP2 VPS52 ZCCHC10 ZNF19 ZNF417 ZNF587	47 interacting genes: AQP6 ARL13B ATP13A2 BAG6 BCAP31 CERS4 CPLX1 CREB3L1 EBP ERGIC3 EXOC3 FKBP2 GET3 HIBADH HSD17B13 JAGN1 KASH5 LMNA MARCHF8 PRKD3 RABAC1 SCN3B SLC30A8 SLC6A4 SLC7A14 SNAP23 SNAP25 SNCA STX11 STX1A STX1B STX2 STX4 STXBP2 STXBP3 SYP SYPL1 TMEM101 TMEM31 TMEM86B TRPC3 VAMP3 VAMP8 VAPA VAPB VCP VMA21
Entrez ID		8676	6844
HPRD ID		09231	01717
Ensembl ID		ENSG00000135604	ENSG00000220205
Uniprot IDs		O75558	F8WCA0 P63027
PDB IDs		Not available	3FIE 3FII 3RK2 3RK3 3RL0 7UDC 9CKX
GO Terms Enriched among Interactors		Identical Protein Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex SNARE Complex Assembly Protein Binding SNAP Receptor Activity SNARE Complex Synaptic Vesicle Docking Synaptic Vesicle Exocytosis SNARE Binding Regulation Of Cellular Response To Stress Regulation Of DNA Repair BLOC-1 Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptic Vesicle Priming Establishment Of Localization In Cell Membrane Docking Establishment Of Organelle Localization Positive Regulation Of Proteolysis Positive Regulation Of Synaptic Transmission Syntaxin Binding Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of RNA Metabolic Process Transcription Coactivator Activity Neurotransmitter Transport Vesicle Fusion Membrane Fusion Long-term Synaptic Potentiation Regulation Of Gene Expression Organelle Membrane Fusion Organelle Localization Establishment Of Vesicle Localization Host-mediated Perturbation Of Symbiont Process DNA Repair-dependent Chromatin Remodeling Regulation Of DNA-templated Transcription Nuclear Androgen Receptor Binding Vesicle Organization Vesicle Docking Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Modulation Of Process Of Another Organism Microtubule-based Process Vesicle Localization Neuron Projection Nucleoplasm	Organelle Localization By Membrane Tethering Membrane Docking Exocytosis SNARE Complex Secretion By Cell SNAP Receptor Activity Vesicle Docking Secretion Organelle Localization Vesicle Fusion SNARE Binding Organelle Membrane Fusion Membrane Fusion Vesicle-mediated Transport Synaptic Vesicle Membrane Organization Vesicle Organization Organelle Fusion Synaptic Vesicle Exocytosis Syntaxin-1 Binding Membrane Organization Regulated Exocytosis Vesicle Docking Involved In Exocytosis Signal Release Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane SNARE Complex Assembly Establishment Of Localization In Cell Membrane Regulation Of Secretion By Cell Establishment Of Protein Localization Calcium-ion Regulated Exocytosis Regulation Of Secretion Intracellular Protein Localization Protein Transport Cellular Localization Vesicle-mediated Transport In Synapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Neurotransmitter Transport Presynapse Regulation Of Exocytosis Specific Granule Regulation Of Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Presynaptic Dense Core Vesicle Exocytosis Hormone Secretion Insulin Secretion Syntaxin Binding Regulation Of Biological Quality Cytoplasmic Vesicle Neuron Projection