VAMP8 and STX7

Number of citations: 172 (PubMedID 40437099)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, affinity chromatography technology, biochemical), HPRD (in vivo)

		VAMP8	STX7
Name		vesicle associated membrane protein 8	syntaxin 7
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Cytosol Plasma Membrane Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Specific Granule Membrane Zymogen Granule Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Mucin Granule	Immunological Synapse Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Plasma Membrane Synaptic Vesicle Endomembrane System Membrane Endocytic Vesicle SNARE Complex Early Endosome Membrane Vesicle Azurophil Granule Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Tertiary Granule Secretory Vesicle
	Molecular Function	SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding
	Biological Process	Vesicle Fusion Autophagy Protein Transport Vesicle-mediated Transport Autophagosome Membrane Docking SNARE Complex Assembly Eosinophil Degranulation Neutrophil Degranulation Protein-containing Complex Organization Symbiont Entry Into Host Cell Defense Response To Virus Mucus Secretion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Secretion By Cell Positive Regulation Of Histamine Secretion By Mast Cell	Positive Regulation Of T Cell Mediated Cytotoxicity Intracellular Protein Transport Vesicle Fusion Vesicle-mediated Transport Vesicle Docking Organelle Localization Organelle Assembly Positive Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Plasma Membrane
Pathways		ER-Phagosome pathway trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	None
GWAS		Coronary artery disease ( 26343387 29212778 32469254 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Myocardial infarction ( 26343387 ) Prostate cancer ( 21743467 ) Sum eosinophil basophil counts ( 27863252 )	A body shape index ( 34021172 ) Cutaneous leishmaniasis ( 32830257 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red cell distribution width ( 32888494 27863252 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		11 interacting genes: CDC25A MLH1 NAPA SNAP23 SNAP25 STX1A STX3 STX4 STX7 UBE2G2 VAMP2	52 interacting genes: ANKS6 AQP6 ARL13B CERS4 CISD2 CREB3 CREB3L1 CYBRD1 EBP ELOVL5 ENTPD2 FAM174A FAM210B FKBP7 GJC3 HSD17B11 HSD17B13 JAGN1 LIME1 LMNA MAPK6 MFF MGST3 MRM1 MTUS1 NAPA REEP1 RETREG3 RIC3 SAR1A SLC10A1 SLC10A6 SLC18A1 SLC35D4 SNAP29 STX1A STX2 STX6 STX8 TM4SF19 TMEM205 TMEM267 TMEM80 TMPRSS2 TMX2 VAMP7 VAMP8 VPS11 VPS16 VPS18 VTI1B ZFYVE27
Entrez ID		8673	8417
HPRD ID		04415	04449
Ensembl ID		ENSG00000118640	ENSG00000079950
Uniprot IDs		B8ZZT4 Q9BV40	O15400
PDB IDs		4WY4 7BV6	Not available
GO Terms Enriched among Interactors		SNAP Receptor Activity SNARE Complex SNARE Binding Membrane Fusion Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Membrane Organization Vesicle Organization Vesicle Docking Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Exocytosis Membrane Docking Positive Regulation Of Synaptic Transmission Syntaxin Binding Neuron Projection Long-term Synaptic Potentiation Azurophil Granule SNARE Complex Assembly Secretion By Cell Vesicle-mediated Transport Specific Granule Synaptic Vesicle Priming Organelle Localization Vesicle-mediated Transport In Synapse Secretion Regulation Of Protein Localization Neurotransmitter Transport Establishment Of Localization In Cell Protein Transport Synaptic Vesicle Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptic Vesicle Calcium-ion Regulated Exocytosis Signal Release Establishment Of Protein Localization Regulation Of Protein Transport Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Chloride Channel Inhibitor Activity Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Intracellular Protein Transport Glutamatergic Synapse Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Cellular Component Assembly	Organelle Membrane Fusion Vesicle Fusion Membrane Fusion SNAP Receptor Activity Organelle Fusion SNARE Complex Organelle Localization By Membrane Tethering Membrane Membrane Docking Vesicle Organization Syntaxin Binding Vesicle Docking Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Binding Chloride Channel Inhibitor Activity Membrane Organization Establishment Of Protein Localization Protein Transport Autophagosome Maturation Intracellular Protein Transport CORVET Complex Organelle Localization Vesicle-mediated Transport Endomembrane System Lysosomal Membrane Intracellular Protein Localization Autophagy Protein Binding Protein-containing Complex Disassembly Vesicle Docking Involved In Exocytosis Establishment Of Localization In Cell Late Endosome Membrane HOPS Complex Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Organelle Organization Endosome To Lysosome Transport Steroid Dehydrogenase Activity Cellular Localization Endoplasmic Reticulum Tubular Network Organization Exocytosis Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Cytoplasmic Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Positive Regulation Of Histamine Secretion By Mast Cell Vesicle Tethering Complex Recycling Endosome Presynaptic Active Zone Membrane