VAMP8 and SNAP25

Number of citations: 0 (PubMedID 10336434)
Data Source: HPRD (in vitro)

		VAMP8	SNAP25
Name		vesicle associated membrane protein 8	synaptosome associated protein 25
Structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Cytosol Plasma Membrane Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane SNARE Complex Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Vesicle Azurophil Granule Membrane Specific Granule Membrane Zymogen Granule Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Mucin Granule	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse
	Molecular Function	SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Vesicle Fusion Autophagy Protein Transport Vesicle-mediated Transport Autophagosome Membrane Docking SNARE Complex Assembly Eosinophil Degranulation Neutrophil Degranulation Protein-containing Complex Organization Symbiont Entry Into Host Cell Defense Response To Virus Mucus Secretion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Secretion By Cell Positive Regulation Of Histamine Secretion By Mast Cell	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis
Pathways		ER-Phagosome pathway trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs		None	Botulinum toxin type A Letibotulinumtoxina
GWAS		Coronary artery disease ( 26343387 29212778 32469254 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Myocardial infarction ( 26343387 ) Prostate cancer ( 21743467 ) Sum eosinophil basophil counts ( 27863252 )	Brain imaging measurements (variance) ( 32047264 ) Cardiac hypertrophy ( 21348951 ) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603 )
Interacting Genes		11 interacting genes: CDC25A MLH1 NAPA SNAP23 SNAP25 STX1A STX3 STX4 STX7 UBE2G2 VAMP2	45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177
Entrez ID		8673	6616
HPRD ID		04415	02637
Ensembl ID		ENSG00000118640	ENSG00000132639
Uniprot IDs		B8ZZT4 Q9BV40	P60880
PDB IDs		4WY4 7BV6	1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV
GO Terms Enriched among Interactors		SNAP Receptor Activity SNARE Complex SNARE Binding Membrane Fusion Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Membrane Organization Vesicle Organization Vesicle Docking Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Exocytosis Membrane Docking Positive Regulation Of Synaptic Transmission Syntaxin Binding Neuron Projection Long-term Synaptic Potentiation Azurophil Granule SNARE Complex Assembly Secretion By Cell Vesicle-mediated Transport Specific Granule Synaptic Vesicle Priming Organelle Localization Vesicle-mediated Transport In Synapse Secretion Regulation Of Protein Localization Neurotransmitter Transport Establishment Of Localization In Cell Protein Transport Synaptic Vesicle Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptic Vesicle Calcium-ion Regulated Exocytosis Signal Release Establishment Of Protein Localization Regulation Of Protein Transport Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Chloride Channel Inhibitor Activity Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Intracellular Protein Transport Glutamatergic Synapse Voltage-gated Potassium Channel Complex Calcium-dependent Protein Binding Cellular Component Assembly	SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport