NUMB and SIAH1

Number of citations: 45 (PubMedID 11752454)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		NUMB	SIAH1
Name		NUMB endocytic adaptor protein	siah E3 ubiquitin protein ligase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Plasma Membrane Clathrin-coated Pit Focal Adhesion Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Glutamatergic Synapse	Nucleus Cytoplasm Early Endosome Cytosol Beta-catenin Destruction Complex
	Molecular Function	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nervous System Development Neuroblast Proliferation Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Cell Differentiation Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984 ) Coronary artery calcification ( 17903303 ) Hemoglobin ( 32888494 ) Macular thickness ( 30535121 ) Multisite chronic pain ( 31194737 33830993 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )	Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 28552196 ) Mean corpuscular hemoglobin ( 32888494 ) Waist circumference ( 28552196 )
Interacting Genes		38 interacting genes: AP2A1 AP2A2 APP DPYSL2 EAF1 EGFR EPS15 FBXO7 FRS3 IQGAP1 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 NRON OLIG1 PALS1 PDZK1IP1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 SPANXN2 TERF2	157 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 AXIN2 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 COPS5 DAB1 DAZAP2 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4C16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN ITSN1 KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NHERF2 NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PCDH17 PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PINK1 PKD1 POU2AF1 PRPF31 PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLAIN1 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX
Entrez ID		8650	6477
HPRD ID		04767	03736
Ensembl ID		ENSG00000133961	ENSG00000196470
Uniprot IDs		P49757	Q8IUQ4
PDB IDs		5NJJ 5NJK	2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ 8HEO 9G0L
GO Terms Enriched among Interactors		Diacylglycerol-dependent Serine/threonine Kinase Activity Enzyme Binding Plasma Membrane Receptor Internalization Positive Regulation Of Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Apical Plasma Membrane Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Signaling Negative Regulation Of Programmed Cell Death Endocytosis Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Superoxide Metabolic Process Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Regulation Of Signal Transduction Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Ubiquitin-protein Transferase Activity Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death AP-2 Adaptor Complex Positive Regulation Of Metabolic Process Regulation Of Cell Communication Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Catabolic Process Extracellular Exosome Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Transport Programmed Cell Death Cell Death Negative Regulation Of Insulin Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Response To Insulin Stimulus	Nucleus Ubiquitin Conjugating Enzyme Activity Protein Binding Ubiquitin Protein Ligase Binding Nucleoplasm Cytoplasm Protein Modification By Small Protein Conjugation Protein Polyubiquitination Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Post-translational Protein Modification Identical Protein Binding Beta-catenin Destruction Complex Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Nuclear Body Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide Binding Protein Ubiquitination Cell Death Microtubule-based Process Apoptotic Process SUMO Transferase Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Microtubule Regulation Of Macromolecule Metabolic Process Microtubule Binding Organelle Organization Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Lateral Ventricle Development Astrocyte Projection Positive Regulation Of Post-translational Protein Modification Establishment Of Mitochondrion Localization UBC13-MMS2 Complex Neuroblast Division In Subventricular Zone Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Adenyl-nucleotide Exchange Factor Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process