OASL and SEZ6L2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		OASL	SEZ6L2
Name		2'-5'-oligoadenylate synthetase like	seizure related 6 homolog like 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Neuronal Cell Body
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding Nucleotidyltransferase Activity Nuclear Thyroid Hormone Receptor Binding	None
	Biological Process	Immune System Process Response To Virus Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Defense Response To Other Organism Antiviral Innate Immune Response Positive Regulation Of RIG-I Signaling Pathway	Adult Locomotory Behavior Cerebellar Purkinje Cell Layer Development Synapse Maturation
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	None
GWAS		Alanine aminotransferase levels ( 33547301 ) C-reactive protein ( 22939635 ) C-reactive protein levels ( 24763700 30388399 ) Cardiovascular disease risk factors ( 21943158 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) N-glycan levels ( 21203500 21908519 ) Serum metabolite levels ( 23093944 ) Type 2 diabetes ( 30054458 )	Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30643258 ) Anthropometric traits ( 19260139 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bitter alcoholic beverage consumption ( 31046077 ) Body fat distribution (arm fat ratio) ( 30664634 ) Response to taxane treatment (paclitaxel) ( 23006423 ) Schizophrenia ( 25056061 28991256 29483656 ) Systemic lupus erythematosus ( 23273568 )
Interacting Genes		4 interacting genes: FILNC1 MBD1 SEZ6L2 THRA	7 interacting genes: ETV5 FOXA1 MTDH OASL TK1 TOX3 UNG
Entrez ID		8638	26470
HPRD ID		04473	06686
Ensembl ID		ENSG00000135114	ENSG00000174938
Uniprot IDs		A0A7P0T9H8 Q15646	A0A087WYL5 A0A0A8K8P7 B7Z5L4 Q6UXD5
PDB IDs		1WH3 4XQ7	Not available
GO Terms Enriched among Interactors		Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Thyroid Hormone Receptor Signaling Pathway Female Courtship Behavior Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Female Receptivity Double-stranded Methylated DNA Binding Unmethylated CpG Binding Transcription By RNA Polymerase II Regulation Of Female Receptivity Regulation Of Thyroid Hormone Receptor Signaling Pathway Type I Pneumocyte Differentiation Female Mating Behavior Negative Regulation Of DNA-templated Transcription Initiation Thyroid Hormone Binding Negative Regulation Of Transcription Initiation By RNA Polymerase II Cerebellar Purkinje Cell Layer Development General Transcription Initiation Factor Binding DNA-templated Transcription Synapse Maturation Cell Aggregation Cartilage Condensation Mating Behavior Retinoic Acid Receptor Signaling Pathway Methyl-CpG Binding Lung Epithelial Cell Differentiation TBP-class Protein Binding Lung Cell Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Reproductive Behavior DNA Methylation-dependent Constitutive Heterochromatin Formation Response To Cold	Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Neuron Differentiation Nucleus Male Germ-line Stem Cell Asymmetric Division Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Respiratory Basal Cell Differentiation Alveolar Secondary Septum Development Fibrillar Center Positive Regulation Of DNA-binding Transcription Factor Activity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Positive Regulation Of Dopaminergic Neuron Differentiation Epithelial Cell Maturation Involved In Prostate Gland Development Prostate Gland Stromal Morphogenesis Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development DNA Synthesis Involved In Mitotic DNA Replication Thymidine Biosynthetic Process Pyrimidine-containing Compound Metabolic Process Thymidine Kinase Activity Base-excision Repair, AP Site Formation Via Deaminated Base Removal Uracil DNA N-glycosylase Activity Double-stranded RNA Binding 2'-5'-oligoadenylate Synthetase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neuron Differentiation Regulation Of DNA-binding Transcription Factor Activity Intercellular Canaliculus Thymidine Metabolic Process Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Positive Regulation Of RNA Metabolic Process Depyrimidination Interleukin-27-mediated Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Mesenchymal-epithelial Cell Signaling Epithelial Cell Differentiation Involved In Prostate Gland Development Deoxyribonucleoside Monophosphate Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Single Strand Break Repair Negative Regulation Of Programmed Cell Death Positive Regulation Of RIG-I Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Asymmetric Cell Division Dorsal/ventral Neural Tube Patterning Pyrimidine Nucleoside Metabolic Process