STC2 and EIF2B3

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		STC2	EIF2B3
Name		stanniocalcin 2	eukaryotic translation initiation factor 2B subunit gamma
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Hormone Activity Enzyme Binding Heme Binding Protein Homodimerization Activity	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Response To Oxidative Stress Embryo Implantation Negative Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Response To Vitamin D Response To Endoplasmic Reticulum Stress Negative Regulation Of Multicellular Organism Growth Response To Peptide Hormone Decidualization Regulation Of Hormone Biosynthetic Process Calcium Ion Homeostasis Cellular Response To Hypoxia Regulation Of Store-operated Calcium Entry	Cytoplasmic Translational Initiation Translation Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Recycling of eIF2:GDP
Diseases		None	Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		A body shape index ( 34021172 ) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353 ) Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 29892015 ) Birth weight ( 31043758 ) Height ( 25429064 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Immunoglobulin A vasculitis ( 28698626 ) Prostate cancer ( 23535732 ) Retinitis pigmentosa ( 33514863 ) Urate levels in overweight individuals ( 25811787 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Platelet distribution width ( 32888494 )
Interacting Genes		11 interacting genes: ADAM11 AIFM1 ARHGEF40 ARRB2 CARHSP1 EIF2B3 PEBP1 POLR2C POLR3F PPP1R8 PTN	5 interacting genes: EIF2S1 EIF2S2 GOLM1 NDUFB8 STC2
Entrez ID		8614	8891
HPRD ID		04717	09379
Ensembl ID		ENSG00000113739	ENSG00000070785
Uniprot IDs		O76061 Q6FHC9	Q9HA31 Q9NR50
PDB IDs		7Y5Q 8A7D 8A7E 8HGH	6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ
GO Terms Enriched among Interactors		None	Eukaryotic Translation Initiation Factor 2 Complex Endoplasmic Reticulum Unfolded Protein Response Translation Initiation Ternary Complex Translation Initiation Factor Activity Histone H3K36me2/H3K36me3 Demethylase Activity Translational Initiation Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Male Germ Cell Proliferation