PLPP1 and FXYD1

Number of citations: 0 (PubMedID 10087003)
Data Source: HPRD (in vitro)

		PLPP1	FXYD1
Name		phospholipid phosphatase 1	FXYD domain containing ion transport regulator 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Caveola Membrane Apical Plasma Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Apical Plasma Membrane T-tubule Sarcolemma
	Molecular Function	Diacylglycerol Diphosphate Phosphatase Activity Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Ceramide-1-phosphate Phosphatase Activity	Chloride Channel Activity Sodium Channel Regulator Activity Transmembrane Transporter Binding Ion Channel Regulator Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Catabolic Process Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Phospholipid Dephosphorylation	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Regulation Of Monoatomic Ion Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Sodium Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane
Pathways		Sphingolipid catabolism	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
GWAS		Cocaine dependence ( 31212010 ) Heel bone mineral density ( 28869591 30598549 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: CREB3 FAHD1 FXYD1 GPR42 SSMEM1	9 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA SLC8A1 YWHAQ
Entrez ID		8611	5348
HPRD ID		06178	03837
Ensembl ID		ENSG00000067113	ENSG00000266964
Uniprot IDs		O14494	O00168
PDB IDs		Not available	2JO1
GO Terms Enriched among Interactors		Negative Regulation Of Protein Glutathionylation Positive Regulation Of Deacetylase Activity Fumarylpyruvate Hydrolase Activity Oxaloacetate Tautomerase Activity Acylpyruvate Hydrolase Activity Acetylpyruvate Hydrolase Activity Positive Regulation Of Monoatomic Ion Transport Oxaloacetate Decarboxylase Activity Release From Viral Latency Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Regulation Of Cardiac Muscle Cell Membrane Potential CCR1 Chemokine Receptor Binding Oxaloacetate Metabolic Process CAMP Response Element Binding Protein Binding Sodium:potassium-exchanging ATPase Complex Regulation Of Metal Ion Transport Induction Of Positive Chemotaxis	Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Regulation Of Striated Muscle Contraction Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Sodium Ion Export Across Plasma Membrane Regulation Of Blood Circulation Regulation Of Muscle System Process Intracellular Potassium Ion Homeostasis Relaxation Of Muscle Intracellular Sodium Ion Homeostasis Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intracellular Monoatomic Cation Homeostasis Sodium Ion Homeostasis Potassium Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Calcium-mediated Signaling T-tubule Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Export Across Plasma Membrane Intracellular Signal Transduction Regulation Of System Process P-type Sodium:potassium-exchanging Transporter Activity Regulation Of Sodium Ion Transport Cellular Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transport Extracellular Exosome Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Sodium:potassium-exchanging ATPase Complex Inorganic Cation Import Across Plasma Membrane Sarcolemma Sperm Flagellum Chemical Homeostasis Intracellular Signaling Cassette Sodium Ion Transmembrane Transport Regulation Of Transport Transmembrane Transporter Binding Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Import Across Plasma Membrane Membrane Repolarization During Action Potential