AKR7A2 and AKR7A3

Number of citations: 77 (PubMedID 38334954)
Data Source: BioGRID (cross-linking study), HPRD (two hybrid)

		AKR7A2	AKR7A3
Name		aldo-keto reductase family 7 member A2	aldo-keto reductase family 7 member A3
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Extracellular Exosome	Cytoplasm Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	Aldose Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Electron Transfer Activity Oxidoreductase Activity Phenanthrene-9,10-epoxide Hydrolase Activity	Protein Binding Alcohol Dehydrogenase (NADP+) Activity Electron Transfer Activity Oxidoreductase Activity Identical Protein Binding NADP+ Binding
	Biological Process	Carbohydrate Metabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process	Aldehyde Metabolic Process Response To Toxic Substance Aflatoxin Catabolic Process
Pathways		Aflatoxin activation and detoxification	Aflatoxin activation and detoxification
GWAS		Blood protein levels ( 30072576 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 )	Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Late-onset Alzheimer's disease ( 27770636 )
Interacting Genes		5 interacting genes: AKR7A3 F2 MCPH1 TRIM63 ZBTB1	5 interacting genes: AKR7A2 CFTR KRT31 KRTAP1-1 TERF2IP
Entrez ID		8574	22977
HPRD ID		04567	07089
Ensembl ID		ENSG00000053371	ENSG00000162482
Uniprot IDs		B4DZX4 O43488 V9HWA2	A0A384MDN8 O95154
PDB IDs		2BP1	2CLP
GO Terms Enriched among Interactors		None	Alcohol Metabolic Process Steroid Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Flavonoid 3'-monooxygenase Activity Dibenzo-p-dioxin Catabolic Process Secondary Metabolic Process Insecticide Metabolic Process Response To Diphenyl Ether Ethylene Metabolic Process Phenanthrene-9,10-epoxide Hydrolase Activity Positive Regulation Of Anion Channel Activity Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Arachidonate Monooxygenase Activity Keratin Filament Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Monoatomic Anion Transport Dibenzo-p-dioxin Metabolic Process Coumarin Metabolic Process Positive Regulation Of Enamel Mineralization Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Response To Iron(III) Ion Demethylase Activity Long-chain Fatty Acid Omega-1 Hydroxylase Activity Intermediate Filament Transepithelial Water Transport Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Response To Ketone Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Long-chain Fatty Acid Omega-hydroxylase Activity Response To Phenylpropanoid Retinoic Acid Biosynthetic Process Lipid Hydroxylation Estrogen 16-alpha-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity Protection From Non-homologous End Joining At Telomere Shelterin Complex Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation