MAPKAPK5 and MYH11

Number of citations: 68 (PubMedID 9628874)
Data Source: HPRD (in vitro)

		MAPKAPK5	MYH11
Name		MAPK activated protein kinase 5	myosin heavy chain 11
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Cytoplasm Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myosin Filament Melanosome Extracellular Exosome
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Actin Filament Binding
	Biological Process	MAPK Cascade Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Dendritic Spine Development Cellular Senescence Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction	Smooth Muscle Contraction Skeletal Muscle Myosin Thick Filament Assembly Actomyosin Structure Organization Elastic Fiber Assembly Cardiac Muscle Cell Development
Pathways		Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs		Fostamatinib	Tetrafluoroaluminate Ion
Diseases		None	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Adult body size ( 32376654 ) Body mass index ( 26426971 ) Coffee consumption ( 29367735 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Mean spheric corpuscular volume ( 32888494 ) Psoriasis ( 28537254 ) Spleen volume ( 34128465 ) Tea consumption ( 33080986 )	Cognitive function ( 25644384 ) Coronary artery disease ( 33020668 29212778 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Haemorrhoidal disease ( 33888516 ) Multiple myeloma (survival) ( 26198393 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311 ) PR interval ( 32439900 ) Pulse pressure ( 27841878 30578418 ) Resting heart rate ( 27798624 29769521 ) Serum immune biomarker levels ( 32066700 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 ) Skin aging measurement ( 31522824 ) Waist-hip ratio ( 23966867 )
Interacting Genes		32 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HMGB1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SNCA SRPK1 SRPK2 TAB1 TP53 YAP1 ZNF282 ZNF576	4 interacting genes: APC DAXX GRB2 MAPKAPK5
Entrez ID		8550	4629
HPRD ID		09467	01174
Ensembl ID		ENSG00000089022	ENSG00000133392
Uniprot IDs		Q8IW41	A0A024QZJ4 P35749
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Cellular Response To Anisomycin Cytosol Kinase Activity Positive Regulation Of Cytokine Production Response To Anisomycin Nucleus Stress-activated MAPK Cascade Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Response To Stress Cellular Response To Stress Phosphorylation Cytoplasm Animal Organ Development Regulation Of Gene Expression Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Protein Localization To Tricellular Tight Junction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process ATP Binding Positive Regulation Of Biosynthetic Process Cellular Senescence Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia P38MAPK Cascade Cellular Response To Radiation Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Postsynapse Cellular Response To Oxygen-containing Compound Cellular Response To UV RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Apoptotic Process Transferase Activity Nucleotide Binding Cellular Response To Oxidative Stress Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Response To Oxidative Stress	Protein Kinase Binding Intracellular Signal Transduction Insulin Receptor Signaling Pathway P53 Binding Ras Protein Signal Transduction Guanyl-nucleotide Exchange Factor Adaptor Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Intracellular Signaling Cassette Cellular Response To Diamide Grb2-EGFR Complex Septin Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Chromosome Organization Regulation Of Organelle Organization Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Sodium Arsenite MAPK Cascade Small GTPase-mediated Signal Transduction Neurotrophin TRKA Receptor Binding Calcium-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Localization To Centrosome Stress-induced Premature Senescence Ubiquitin Protein Ligase Binding Wnt Signalosome Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleoplasm Beta-catenin Destruction Complex Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cellular Response To Stress Gamma-catenin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Centrosome Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Tissue Morphogenesis Protein Kinase Regulator Activity Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Arsenic-containing Substance Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity MAP Kinase Kinase Activity Negative Regulation Of Microtubule Depolymerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Biogenesis