EAF1 and ELL2

Number of citations: 0 (PubMedID 11418481)
Data Source: HPRD (in vivo)

		EAF1	ELL2
Name		ELL associated factor 1	elongation factor for RNA polymerase II 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intercellular Bridge	Nucleus Nucleoplasm Transcription Elongation Factor Complex
	Molecular Function	Transcription Elongation Factor Activity Protein Binding	Cis-regulatory Region Sequence-specific DNA Binding Protein Binding
	Biological Process	Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II	Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
GWAS		No GWAS studies recorded	Albumin-globulin ratio ( 29403010 ) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199 ) Body mass index ( 26426971 ) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444 ) IgA levels ( 28628107 ) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG sialylation phenotypes (multivariate analysis) ( 28878392 ) Mean corpuscular hemoglobin ( 32888494 ) Multiple myeloma ( 26007630 33875642 ) Multiple myeloma and monoclonal gammopathy ( 26007630 ) Non-albumin protein levels ( 29403010 ) Serum total protein levels ( 23022100 ) Telomere length ( 30185882 )
Interacting Genes		54 interacting genes: AP2M1 APP ARID4B BEND7 CCDC150 CCDC33 CDK9 CEP70 CEP76 DNTTIP1 DPPA4 DRC4 ELL ELL2 FAM228A GADD45GIP1 GCSAML GOLGA6L9 GPRASP3 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM28 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620	7 interacting genes: AQP2 CASK EAF1 EXOC8 PRKAB2 RNF181 SIAH1
Entrez ID		85403	22936
HPRD ID		12209	11798
Ensembl ID		ENSG00000144597	ENSG00000118985
Uniprot IDs		Q96JC9	O00472 Q59FW6
PDB IDs		7OKX 7OKY	2E5N 5JW9 7OKX 7OKY
GO Terms Enriched among Interactors		Transcription By RNA Polymerase II DNA-templated Transcription Transcription Elongation Factor Complex Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Receptor Internalization TORC1 Complex Assembly Regulation Of RNA Metabolic Process Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Regulation Of Receptor-mediated Endocytosis Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Elongation Neuroblast Proliferation SnRNA Transcription By RNA Polymerase II Positive Regulation Of Receptor-mediated Endocytosis Transcription Factor TFIIH Core Complex Regulation Of Macromolecule Metabolic Process Transcription Factor TFIIH Holo Complex Negative Regulation Of Neuroblast Proliferation Nucleus Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process SnRNA Transcription Regulation Of Gene Expression Chromatin Remodeling Positive Regulation Of DNA-templated Transcription, Elongation RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of JNK Cascade Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase III	None