UBASH3B and SLC25A48

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		UBASH3B	SLC25A48
Name		ubiquitin associated and SH3 domain containing B	solute carrier family 25 member 48
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding	Protein Binding Transmembrane Transporter Activity
	Biological Process	Signal Transduction Negative Regulation Of Signal Transduction Platelet Activation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Aggregation Negative Regulation Of Platelet Aggregation	Transmembrane Transport
GWAS		Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Blood urea nitrogen levels ( 31152163 ) Cholesterol, total ( 25961943 20686565 24097068 ) Chronotype ( 30696823 ) Diastolic blood pressure ( 30224653 ) Eye length ( 30174134 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) HDL cholesterol ( 24097068 20686565 ) HDL cholesterol levels ( 32203549 ) High density lipoprotein cholesterol levels ( 33339817 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376 ) Pemphigus vulgaris ( 29857070 ) Serum immune biomarker levels ( 32066700 ) Stroke ( 26089329 ) Systolic blood pressure ( 30578418 ) Total cholesterol levels ( 28334899 )	Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321 ) Cerebrospinal fluid t-tau levels ( 29274321 ) Obesity-related traits ( 23251661 ) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665 ) Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (dichotomous) ( 28628665 )
Interacting Genes		51 interacting genes: BBC3 CBL CBLB CCDC74B CUL3 DAZAP2 DISC1 DLGAP2 DMRT3 DOC2A DTX3 EFS FAM168A HOXB2 INCA1 JAK2 KAT5 KDM1A KHDRBS1 KPRP LMO2 LZTS2 MAP3K1 PIAS2 PKP4 PRKN PRR35 PSMB1 PTPN21 RCHY1 REL RNF216 RNF41 SHC1 SLC25A48 SPRY2 SYK TCF4 TEPSIN TNKS TP53BP2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B WASL	14 interacting genes: ATN1 CCDC57 CYSRT1 EFEMP2 GUCD1 KRTAP10-3 KRTAP10-7 MGAT5B MID2 MTUS2 PNMA1 RBPMS TRAF1 UBASH3B
Entrez ID		84959	153328
HPRD ID		16463	14098
Ensembl ID		ENSG00000154127	ENSG00000145832
Uniprot IDs		Q8TF42	J3KQI1 Q6ZT89
PDB IDs		2CPW 2E5K 5VR6 5W5G 8U5M 8U7E	Not available
GO Terms Enriched among Interactors		Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Protein Modification Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin Protein Ligase Activity Proteolysis Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Ubiquitination Protein Autoubiquitination Protein Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Transferase Activity Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Metabolic Process Protein Monoubiquitination Receptor Tyrosine Kinase Binding Positive Regulation Of Metabolic Process Protein Binding Regulation Of Protein Metabolic Process Protein K11-linked Ubiquitination Phosphotyrosine Residue Binding Cytosol SH3 Domain Binding Regulation Of Primary Metabolic Process Regulation Protein Catabolic Process At Postsynapse Apoptotic Signaling Pathway Macromolecule Metabolic Process Organelle Localization P53 Binding Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Protein Polymerization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway	None