TRIM52 and RNF114

Number of citations: 44 (PubMedID 22493164)
Data Source: BioGRID (two hybrid)

		TRIM52	RNF114
Name		tripartite motif containing 52	ring finger protein 114
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Signal Transduction Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription Defense Response To Virus Protein Autoubiquitination	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation
Pathways		None	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		No GWAS studies recorded	Gut microbiota (beta diversity) ( 27723756 ) Inflammatory skin disease ( 25574825 ) Psoriasis ( 20953189 23143594 25574825 25903422 ) Psoriasis vulgaris ( 26626624 ) Systemic lupus erythematosus ( 24871463 )
Interacting Genes		6 interacting genes: APP NEDD4 RNF114 RNF126 RSPH1 TRIM41	29 interacting genes: AK5 BMI1 EVI2A HSPA5 MAP3K1 MAPK3 RNF38 RPSA SMURF1 TRAF4 TRAF6 TRAIP TRIM52 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2U UBE2W UEVLD
Entrez ID		84851	55905
HPRD ID		10283	10329
Ensembl ID		ENSG00000183718	ENSG00000124226
Uniprot IDs		A0A8I5KQM7 A0A8I5KRY2 A0A8I5KW90 A0A8I5KXQ2 A0A8I5KYD8 Q96A61	Q9Y508
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Monoubiquitination Ubiquitin Protein Ligase Activity Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Polyubiquitination Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein K63-linked Ubiquitination Formation Of Structure Involved In A Symbiotic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Modification Process Modification-dependent Protein Catabolic Process Channel Inhibitor Activity Phosphothreonine Residue Binding Ubiquitin-dependent Protein Catabolic Process Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Radial Spoke Head 1 Radial Spoke Head 3 Proteolysis Involved In Protein Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Defense Response To Symbiont Axon Midline Choice Point Recognition Defense Response To Other Organism Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling	Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Transferase Activity Protein Modification Process Protein Metabolic Process Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process ATP Binding Macromolecule Catabolic Process Macromolecule Metabolic Process Proteolysis Nucleotide Binding Ubiquitin Protein Ligase Activity Protein Monoubiquitination Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Regulation Of Protein Ubiquitination Nucleus Cytosol ISG15-protein Conjugation Positive Regulation Of Protein Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activator Activity TORC1 Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway DNA Damage Response Antiviral Innate Immune Response Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Signal Transduction TOR Signaling Ubiquitin-like Protein Transferase Activity