ZNF496 and ZZZ3

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		ZNF496	ZZZ3
Name		zinc finger protein 496	zinc finger ZZ-type containing 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nucleolus Mitotic Spindle ATAC Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Regulation Of Cell Division Regulation Of Cell Cycle
Pathways		Generic Transcription Pathway	HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
GWAS		Chromium levels ( 26025379 ) Platelet distribution width ( 32888494 )	A body shape index ( 34021172 ) Body mass index ( 28448500 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically active individuals ( 28448500 ) Height ( 31562340 ) Hip circumference ( 25673412 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Obesity ( 23563607 ) Platelet count ( 32888494 ) Type 2 diabetes (age of onset) ( 28060188 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		22 interacting genes: ARR3 CBX3 JADE2 NR3C1 NSD1 PGBD1 POLR3D PPARG RAI1 RNF8 SCAND1 SSX3 SUMO2 SUMO3 SUPT5H TRIM28 ZKSCAN4 ZNF446 ZSCAN12 ZSCAN21 ZSCAN22 ZZZ3	21 interacting genes: BLZF1 CARD9 DNAJB11 EFHC2 EPS8 FAM124A GATA1 GOLGA2 IKBKG LZTR1 MAML3 PBXIP1 PCBD2 PICK1 PPP1R13B TRAF2 TRIM22 ZBTB9 ZNF212 ZNF496 ZNF513
Entrez ID		84838	26009
HPRD ID		15805	15907
Ensembl ID		ENSG00000162714	ENSG00000036549
Uniprot IDs		Q96IT1	Q8IYH5
PDB IDs		Not available	2FC7 2YUM 6E83 6E86
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Zinc Ion Binding Nucleus Chromatin Binding Nucleoplasm RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Sumoylation Chromatin Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Tag Activity DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Positive Regulation Of RNA Metabolic Process SUMO Transferase Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Ubiquitin-like Protein Ligase Binding Negative Regulation Of DNA-templated Transcription, Elongation Cellular Response To Dexamethasone Stimulus RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Nuclear Glucocorticoid Receptor Activity Transcription Coregulator Binding Chromatin Remodeling Response To Dexamethasone Regulation Of DNA Binding Negative Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Heterochromatin Positive Regulation Of Metabolic Process Cellular Response To Glucocorticoid Stimulus Positive Regulation Of MiRNA Transcription Nuclear Receptor Activity Chromatin Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing	Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding