CDC42BPA and PPP1R12C

Number of citations: 0 (PubMedID 11399775)
Data Source: HPRD (in vivo)

		CDC42BPA	PPP1R12C
Name		CDC42 binding protein kinase alpha	protein phosphatase 1 regulatory subunit 12C
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Lamellipodium Cell Leading Edge Actomyosin Cell Projection Extracellular Exosome	Stress Fiber Cytoplasm Cytoskeleton
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Phosphatase Regulator Activity Protein Kinase Binding
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Cell Migration Actin Cytoskeleton Organization Actomyosin Structure Organization	Signal Transduction Neuron Projection Morphogenesis
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle	None
GWAS		Blond vs. brown/black hair color ( 30531825 ) Blood urea nitrogen levels ( 31152163 ) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697 ) Diastolic blood pressure ( 28135244 ) Low density lipoprotein cholesterol levels ( 33339817 ) Macular thickness ( 30535121 ) Mercury levels ( 26025379 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Optic cup area ( 25631615 31798171 ) Optic disc area ( 25631615 31798171 28073927 ) Optic disc size ( 31809533 ) SAPHO syndrome ( 33816493 ) Smoking initiation ( 33082346 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist circumference adjusted for body mass index ( 34021172 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: CDC42 LIMK1 LIMK2 MYL2 MYL9 PPM1A PPP1R12C SNAPIN TAF1 USP7	27 interacting genes: AIRIM ATP6V1H ATXN7 BHLHA9 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 FMR1 FXR1 FXR2 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SMARCA2 SPECC1L THOC1 TSFM USHBP1
Entrez ID		8476	54776
HPRD ID		04562	11452
Ensembl ID		ENSG00000143776	ENSG00000125503
Uniprot IDs		A0A0A0MRJ0 A0A0A0MRJ1 Q5VT25	Q9BZL4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Actin Filament-based Process Actin Cytoskeleton Organization Supramolecular Fiber Organization Myosin Heavy Chain Binding Actomyosin Structure Organization Heart Contraction Cytoskeleton Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Organelle Organization Cytoskeleton Organization Myofibril Assembly Heart Process Structural Constituent Of Muscle Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Stress Fiber Assembly Actin Filament Organization Establishment Of Organelle Localization Regulation Of Cell Projection Organization Myosin Complex Myofibril Regulation Of Intracellular Transport Positive Regulation Of Actin Filament Bundle Assembly Actin Filament Bundle Assembly Muscle Cell Fate Specification Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Late Endosome To Lysosome Transport Actin Filament Bundle Organization P53 Binding Cellular Component Assembly Protein Serine Kinase Activity Protein Phosphorylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Component Organization GBD Domain Binding Storage Vacuole Organelle Transport Along Microtubule Negative Regulation Of Protein Autoubiquitination Stress Fiber Phosphorylation Protein Modification Process Regulation Of Cell Growth Regulation Of Stress Fiber Assembly Protein Serine/threonine Kinase Activity Developmental Process Endothelin Receptor Signaling Pathway Involved In Heart Process Establishment Of Vesicle Localization Symbiont-mediated Disruption Of Host Cell PML Body Organelle Localization	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity MRNA Transport Translation Regulator Activity RNA Transport Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Nucleobase-containing Compound Transport RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Regulation Of Neuronal Synaptic Plasticity MRNA Export From Nucleus Positive Regulation Of MiRNA-mediated Gene Silencing Transcription Export Complex Cytosol Protein Heterodimerization Activity Positive Regulation Of Interleukin-1 Production RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Nucleolus MRNA Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Interleukin-1 Production Positive Regulation Of Positive Chemotaxis Dentate Gyrus Development Regulation Of Post-transcriptional Gene Silencing Nuclear Export MRNA 3'-UTR Binding Negative Regulation Of Microtubule Depolymerization Protein Binding Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Muscle Cell Fate Specification Myosin-light-chain-phosphatase Activity Regulation Of Microtubule Depolymerization Neural Crest Cell Delamination Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Positive Regulation Of Catabolic Process Cytoplasm Neuron Projection Nucleic Acid Binding RNA Binding Positive Regulation Of Translation