PSRC1 and SRGN

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		PSRC1	SRGN
Name		proline and serine rich coiled-coil 1	serglycin
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Spindle Microtubule Microtubule Cytoskeleton Midbody	Extracellular Region Extracellular Space Lysosome Golgi Apparatus Secretory Granule Extracellular Matrix Platelet Alpha Granule Lumen Mast Cell Granule Cytolytic Granule
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Microtubule Bundle Formation Mitotic Metaphase Chromosome Alignment Negative Regulation Of Cell Growth Positive Regulation Of Microtubule Polymerization Positive Regulation Of DNA-templated Transcription Cell Division Regulation Of Mitotic Spindle Organization	Negative Regulation Of Cytokine Production Apoptotic Process Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways		None	Platelet degranulation
GWAS		Abdominal aortic aneurysm ( 27899403 ) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Alanine aminotransferase levels ( 33547301 ) Cholesterol ( 31902109 ) Cholesterol, total ( 20686565 ) Coronary artery disease ( 29212778 32469254 ) Coronary heart disease ( 21378988 17634449 ) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) LDL cholesterol ( 19060910 20686565 19060906 21347282 18262040 18193044 18193043 18179892 ) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lipid metabolism phenotypes ( 19936222 ) Lipoprotein (a) levels ( 33730874 ) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857 ) Low density lipoprotein cholesterol levels ( 30718733 ) Medication use (salicylic acid and derivatives) ( 31015401 ) Metabolite levels ( 21909109 ) Myocardial infarction (early onset) ( 19198609 ) Parental lifespan ( 30642433 ) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965 ) Parental longevity (father's attained age) ( 29227965 ) Progranulin levels ( 29186428 21087763 ) Response to statin therapy ( 20339536 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 )	Glycemic traits (pregnancy) ( 23903356 ) Hemoglobin levels ( 32327693 )
Interacting Genes		8 interacting genes: AKT1 APP ASB7 AURKA CDK1 MAPRE3 PLK1 SRGN	17 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB NCALD PEX12 PF4 PSRC1 SGTA SGTB UBQLN1 UBQLN2 UBQLN4 UBR4
Entrez ID		84722	5552
HPRD ID		13127	01513
Ensembl ID		ENSG00000134222	ENSG00000122862
Uniprot IDs		A8K0M8 Q6PGN9	P10124
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Proteolysis Positive Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Protein Catabolic Process Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Spindle Microtubule Centrosome Cycle Midbody G2/M Transition Of Mitotic Cell Cycle Protein Localization To Cytoskeleton Spindle Midzone Cell Cycle G2/M Phase Transition Spindle Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Microtubule Cytoskeleton Protein Localization To Organelle Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Protein Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Protein Localization To Nucleus Microtubule-based Process Mitotic Nuclear Membrane Disassembly Cilium Disassembly Protein Serine Kinase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Centrosome Separation Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Phosphorylation Apoptotic Process Regulation Of Cell Cycle G2/M Phase Transition Protein Serine/threonine Kinase Activity Nuclear Membrane Disassembly Programmed Cell Death Cell Death Microtubule Cytoskeleton Organization Involved In Mitosis Membrane Disassembly Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Regulation Of Postsynapse Organization Microtubule Cytoskeleton Organization	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Proteolysis Involved In Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRC Complex Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Macromolecule Catabolic Process Protein Targeting To ER Response To Stress Proteasomal Protein Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Identical Protein Binding Establishment Of Protein Localization To Organelle Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Targeting To Membrane Positive Regulation Of Protein Catabolic Process Cellular Response To Stress Autophagosome Response To Endoplasmic Reticulum Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Catabolic Process Cytosol Autophagy Catabolic Process Monocyte Chemotaxis Organelle Organization Protein Insertion Into ER Membrane Regulation Of Autophagy Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Cytokine-mediated Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Molecular Adaptor Activity Regulation Of Macroautophagy Negative Regulation Of Store-operated Calcium Channel Activity Establishment Of Protein Localization Hsp70 Protein Binding