USP32 and TRIM46

Number of citations: 42 (PubMedID 23105109)
Data Source: BioGRID (two hybrid)

		USP32	TRIM46
Name		ubiquitin specific peptidase 32	tripartite motif containing 46
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Endomembrane System Membrane	Cytoplasm Cytoskeleton Axon Cell Projection Axon Initial Segment Main Axon Axon Cytoplasm Proximal Neuron Projection
	Molecular Function	Cysteine-type Deubiquitinase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Zinc Ion Binding Metal Ion Binding
	Biological Process	Proteolysis Protein Deubiquitination Positive Regulation Of TORC1 Signaling	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Neuron Migration Axonogenesis Negative Regulation Of Axon Extension Regulation Of Protein Localization Anterograde Synaptic Vesicle Transport Protein Localization To Axon Positive Regulation Of Anterograde Dense Core Granule Transport
Pathways		None	Interferon gamma signaling
GWAS		Interleukin-6 levels ( 33517400 )	Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 29059683 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Estimated glomerular filtration rate ( 31152163 ) Inflammatory bowel disease ( 28067908 ) Microalbuminuria ( 31511532 ) Serum CC16 levels ( 32839289 ) Serum uric acid levels ( 30993211 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Urate levels ( 31578528 31985003 23263486 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737 )
Interacting Genes		13 interacting genes: ANKRD29 DYRK1A MEOX2 MTNR1A NCK2 RAB35 RBCK1 RNF144A TRIM3 TRIM46 TRIM74 UBC ZDHHC17	20 interacting genes: AK5 APP BRCA1 CBLC MDM4 MTNR1B OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2D2 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32
Entrez ID		84669	80128
HPRD ID		07612	15563
Ensembl ID		ENSG00000170832	ENSG00000163462
Uniprot IDs		Q8NFA0	A0A087WUH1 B7Z4F9 F5GYK0 Q7Z4K8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Modification Process Histone H3T45 Kinase Activity Endosome Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Immune System Process Ubiquitin Protein Ligase Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Anterograde Dense Core Granule Transport	Post-translational Protein Modification Proteolysis Protein Modification Process Protein Metabolic Process Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cysteine-type Peptidase Activity Protein Ubiquitination Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Transferase Activity Ubiquitin Conjugating Enzyme Activity Protein K27-linked Deubiquitination Ubiquitin-protein Transferase Activity Peptidase Activity Protein Polyubiquitination Regulation Of Signal Transduction Ubiquitin-modified Histone Reader Activity Monoubiquitinated Protein Deubiquitination Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Catabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RIG-I Signaling Pathway Regulation Of Cellular Response To Stress Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Repair Negative Regulation Of ERBB Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Stability Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Pyrimidine-containing Compound Biosynthetic Process Positive Regulation Of Error-prone Translesion Synthesis DADP Biosynthetic Process