FBN3 and RPS6KA6

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		FBN3	RPS6KA6
Name		fibrillin 3	ribosomal protein S6 kinase A6
Structure		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Constituent Conferring Elasticity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Glucose Metabolic Process Signal Transduction Glucose Homeostasis Camera-type Eye Development Embryonic Eye Morphogenesis	Signal Transduction Central Nervous System Development DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Fostamatinib
GWAS		Attention deficit hyperactivity disorder ( 30563984 ) Macular telangiectasia type 2 ( 33654266 ) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Refractive error ( 32231278 ) Serum metabolite levels ( 33031748 ) Serum metabolite ratios in chronic kidney disease ( 29545352 )	No GWAS studies recorded
Interacting Genes		13 interacting genes: ANXA7 BID C11orf58 CDKN1A DAZAP2 GADD45A GSK3B NUDT21 PIK3R3 RPN2 RPS6KA6 TK1 TSC22D1	28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746
Entrez ID		84467	27330
HPRD ID		10538	02250
Ensembl ID		ENSG00000142449	ENSG00000072133
Uniprot IDs		A0A494C0D8 A8KAY2 Q75N90	A0AAU7BMN7 A0AAU7BMR9 A0AAU7BMT2 A0AAU7BN28 Q9UK32
PDB IDs		Not available	6G76 6G77 6G78
GO Terms Enriched among Interactors		Signal Transduction In Response To DNA Damage Positive Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Nuclear Body Protein Serine/threonine Kinase Binding Positive Regulation Of Membrane Permeability Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Catalytic Activity Regulation Of Programmed Cell Death Negative Regulation Of Developmental Process Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Apoptotic Signaling Pathway Regulation Of Membrane Permeability Negative Regulation Of Kinase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Reactive Oxygen Species Metabolic Process PCNA-p21 Complex Cell Cycle G1/S Phase Transition Negative Regulation Of Cardiac Muscle Tissue Regeneration G1/S Transition Of Mitotic Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein P53 Binding Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Stem Cell Differentiation Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Insulin Receptor Signaling Pathway Thymidine Kinase Activity Positive Regulation Of Pro-B Cell Differentiation Negative Regulation Of Embryonic Development DNA Damage Response Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction DNA Synthesis Involved In Mitotic DNA Replication Protein Tetramerization Positive Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Mesoderm Development Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Negative Regulation Of Protein Phosphorylation Cellular Response To Cell-matrix Adhesion Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation	Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Vitamin D Receptor Binding Developmental Maturation Positive Regulation Of RNA Metabolic Process Labyrinthine Layer Blood Vessel Development