DUSP11 and SRSF7

Number of citations: 0 (PubMedID 9685386)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		DUSP11	SRSF7
Name		dual specificity phosphatase 11	serine and arginine rich splicing factor 7
Structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Mitochondrion Nuclear Speck Intercellular Bridge	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Extracellular Exosome
	Molecular Function	RNA Binding Polynucleotide 5'-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphatase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	RNA Processing Protein Dephosphorylation	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor
Pathways		None	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
GWAS		Creatinine levels ( 20383145 ) Lean body mass ( 28552196 ) Metabolite levels ( 21931564 ) Serum metabolite levels ( 23093944 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: QARS1 SRSF7 SRSF9	20 interacting genes: CCNL2 CDK19 CDK6 CEBPA CPSF6 DUSP11 FBXO7 LUC7L LUC7L2 NEDD4 NXF1 OGT PCBP2 PRPF38A RNPS1 SDCBP SREK1 SRPK1 SRPK2 UBC
Entrez ID		8446	6432
HPRD ID		04368	08991
Ensembl ID		ENSG00000144048	ENSG00000115875
Uniprot IDs		O75319	C9JAB2 Q16629
PDB IDs		4JMJ 4MBB 4NYH	2HVZ
GO Terms Enriched among Interactors		Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process RNA Metabolic Process Protein Domain Specific Binding MRNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process RNA Splicing Aminoacyl-tRNA Synthetase Multienzyme Complex Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade Nucleic Acid Metabolic Process Nuclear Speck MRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleic Acid Binding MRNA Metabolic Process Negative Regulation Of Metabolic Process MRNA Splice Site Recognition TRNA Aminoacylation For Protein Translation Regulation Of Stress-activated Protein Kinase Signaling Cascade Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Regulation Of Stress-activated MAPK Cascade RNA Processing Protein Kinase Inhibitor Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression	Nucleoplasm Nuclear Speck Nucleus RNA Binding MRNA Metabolic Process MRNA Binding MRNA Processing RNA Metabolic Process Regulation Of RNA Splicing RNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding RNA Splicing Protein-RNA Complex Assembly Regulation Of Cell Cycle U2-type Prespliceosome U1 SnRNP Macromolecule Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Hemopoiesis Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of MRNA Processing Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Protein Serine Kinase Activity Cyclin D2-CDK6 Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Formation Of Structure Involved In A Symbiotic Process Interleukin-5 Receptor Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Exon-exon Junction Complex Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Protein Targeting Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Response To Vitamin B2 C/EBP Complex Protein Localization To Lysosome Protein Modification Process Channel Inhibitor Activity